SCHEMBL896892

SCHEMBL896892

COc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)c(CO)c2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 20/20 1.00
PTGS1 P23219 2/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8035008 0.93 PTGS2 (0.86) PTGS2
SCHEMBL8023925 0.93 PTGS2 (0.86) PTGS2PTGS1
SCHEMBL8023471 0.91 PTGS2 (1.00) PTGS2PTGS1
SCHEMBL8023228 0.91 PTGS2 (1.00) PTGS2PTGS1
SCHEMBL5430673 0.89 PTGS2 (1.00) PTGS2PTGS1
SCHEMBL8023451 0.89 PTGS2 (0.84) PTGS2
SCHEMBL8039712 0.89 PTGS2 (0.80) PTGS2PTGS1
SCHEMBL8034991 0.88 PTGS2 (0.83) PTGS2
SCHEMBL8032904 0.87 PTGS2 (1.00) PTGS2PTGS1
SCHEMBL8032915 0.87 PTGS2 (0.96) PTGS2PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2000066562-A1 PYRAZOLES HAVING ANTIINFLAMMATORY ACTIVITY DR. REDDY'S RESEARCH FOUNDATION (IN) 2000-11-09 WO claimed
WO-2014176460-A1 METHODS OF TREATING BEHAVIORIAL AND/OR MENTAL DISORDERS CHAU DAVID T (US) 2014-10-30 WO disclosed
US-8793078-B2 Method for predicting activation energy using atomic fingerprint descriptor or atomic descriptor BIOINFORMATICS & MOLECULAR DESIGN RESEARCH CENTER (KR) 2014-07-29 US disclosed
US-8486922-B2 Composition CHEN CHIEN-HUNG (TW) 2013-07-16 US disclosed
US-20120183600-A1 NOVEL COMPOSITION FOR TREATING METABOLIC SYNDROME AND OTHER CONDITIONS CHEN CHIEN-HUNG (US) 2012-07-19 US disclosed
US-20120084012-A1 METHOD FOR PREDICTING ACTIVATION ENERGY USING ATOMIC FINGERPRINT DESCRIPTOR OR ATOMIC DESCRIPTOR BIOINFORMATICS & MOLECULAR DESIGN RESEARCH CENTER (KR) 2012-04-05 US disclosed
US-20110213558-A1 METHOD FOR PREDICTING ACTIVATION ENERGY USING AN ATOMIC FINGERPRINT DESCRIPTOR OR AN ATOMIC DESCRIPTOR BIOINFORMATICS & MOLECULAR DESIGN RESEARCH CENTER (KR) 2011-09-01 US disclosed
EP-2354987-A2 METHOD FOR PREDICTING ACTIVATION ENERGY USING AN ATOMIC FINGERPRINT DESCRIPTOR OR AN ATOMIC DESCRIPTOR Bioinformatics&Molecular Design Research Center (KR) 2011-08-10 EP disclosed
WO-2010056053-A2 METHOD FOR PREDICTING ACTIVATION ENERGY USING AN ATOMIC FINGERPRINT DESCRIPTOR OR AN ATOMIC DESCRIPTOR 사단법인 분자설계연구소 (KR) 2010-05-20 WO disclosed
WO-2000066562-A1 PYRAZOLES HAVING ANTIINFLAMMATORY ACTIVITY DR. REDDY'S RESEARCH FOUNDATION (IN) 2000-11-09 WO disclosed