Methylprednisolone Hemisuccinate

SCHEMBL8968978

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nearest known ligand 0.64

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Methylprednisolone Hemisuccinate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	NR3C1 known ✓	P04150	6/20	0.58

▸	CYP3A4	P08684	7/20	0.64

▸	MAPT	P10636	1/20	0.64

▸	HIF1A	Q16665	8/20	0.59

▸	LMNA	P02545	3/20	0.58

▸	CHRM1	P11229	2/20	0.56

▸	CHRM4	P08173	1/20	0.56

▸	CHRM5	P08912	1/20	0.56

▸	CHRM3	P20309	1/20	0.56

▸	HRH1	P35367	1/20	0.56

▸	PIN1	Q13526	1/20	0.56

▸	CHRM2	P08172	1/20	0.56

▸	CYP2C9	P11712	1/20	0.55

▸	CNR1	P21554	1/20	0.55

▸	TBXA2R	P21731	1/20	0.55

▸	SMN1; SMN2	Q16637	1/20	0.55

▸	PGR	P06401	2/20	0.54

▸	AR	P10275	2/20	0.54

▸	F2	P00734	1/20	0.54

▸	ALDH1A1	P00352	1/20	0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Methylprednisolone Hemisuccinate SCHEMBL582372	0.86	HIF1A (0.79)	CYP3A4HIF1ANR3C1LMNACYP2C9
SCHEMBL16018298	0.86	HIF1A (0.66)	CYP3A4MAPTHIF1ANR3C1LMNA
SCHEMBL16018296	0.85	HIF1A (0.65)	CYP3A4MAPTHIF1ANR3C1LMNA
SCHEMBL16018300	0.85	HIF1A (0.65)	CYP3A4MAPTHIF1ANR3C1LMNA
Prednisolone Phosphoric Acid SCHEMBL7998176	0.85	CYP3A4 (0.71)	CYP3A4MAPTHIF1ANR3C1LMNA
SCHEMBL16018294	0.84	HIF1A (0.64)	CYP3A4MAPTHIF1ANR3C1LMNA
SCHEMBL16018297	0.84	HIF1A (0.64)	CYP3A4MAPTHIF1ANR3C1LMNA
Dexamethasone SCHEMBL3877338	0.84	CYP3A4 (0.69)	CYP3A4HIF1ANR3C1LMNACYP2C9
Betamethasone SCHEMBL20576476	0.84	CYP3A4 (0.69)	CYP3A4HIF1ANR3C1LMNACYP2C9
Prednisolone Phosphoric Acid SCHEMBL1930858	0.84	CYP3A4 (0.69)	CYP3A4MAPTHIF1ANR3C1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-5486160-A	Device and method for the combined electropharmacological treatment of the bladder and the prostatic urethra	PHYSION S.R.L. (IT)	1996-01-23	—	—	US	disclosed