Methylprednisolone Hemisuccinate

Methylprednisolone Hemisuccinate

SCHEMBL582372

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nearest known ligand 0.79

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Methylprednisolone Hemisuccinate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR3C1 known ✓ P04150 6/20 0.70
HIF1A Q16665 9/20 0.79
LMNA P02545 2/20 0.79
PGR P06401 5/20 0.64
CYP3A4 P08684 5/20 0.64
AR P10275 2/20 0.64
F2 P00734 1/20 0.64
PMP22 Q01453 1/20 0.60
TSHR P16473 1/20 0.60
NFKB1 P19838 1/20 0.60
HSD17B10 Q99714 3/20 0.58
ABCB11 O95342 2/20 0.58
ALDH1A1 P00352 1/20 0.58
ABCC4 O15439 1/20 0.58
NR1I2 O75469 1/20 0.58
PDE4D Q08499 1/20 0.58
KMT2A Q03164 1/20 0.57
TNF P01375 2/20 0.56
IL6 P05231 1/20 0.56
SERPINA6 P08185 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Methylprednisolone Hemisuccinate SCHEMBL40947 0.90 NR3C1 (0.85) HIF1ALMNANR3C1PGRCYP3A4
Methylprednisolone Hemisuccinate SCHEMBL10953512 0.90 NR3C1 (0.85) HIF1ALMNANR3C1PGRCYP3A4
Methylprednisolone Hemisuccinate SCHEMBL1169509 0.90 NR3C1 (0.85) HIF1ALMNANR3C1PGRCYP3A4
Prednisolone Hemisuccinate SCHEMBL122046 0.89 HIF1A (1.00) HIF1ALMNANR3C1PGRCYP3A4
Prednisolone Hemisuccinate SCHEMBL871872 0.89 HIF1A (1.00) HIF1ALMNANR3C1PGRCYP3A4
Methylprednisolone Hemisuccinate SCHEMBL18321784 0.88 NR3C1 (0.81) HIF1ALMNANR3C1PGRCYP3A4
Methylprednisolone Phosphoric Acid SCHEMBL1237362 0.87 PGR (0.78) HIF1ALMNANR3C1PGRCYP3A4
Methylprednisolone Hemisuccinate SCHEMBL8968978 0.86 CYP3A4 (0.64) HIF1ALMNANR3C1PGRCYP3A4
Methylprednisolone Hemisuccinate SCHEMBL1030222 0.86 NR3C1 (0.79) HIF1ALMNANR3C1PGRCYP3A4
Prednisolone Hemisuccinate SCHEMBL3710487 0.86 HIF1A (0.94) HIF1ALMNANR3C1PGRCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 159 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12042561-B2 Hydrophobic molecule-induced branched polymer aggregates and their use ANP TECHNOLOGIES, INC. (US) 2024-07-23 US disclosed
US-20240016754-A1 PHARMACEUTICAL COMPOSITION CONTAINING TAXANE NANOAGGREGATES AND USE THEREOF FULGENT GENETICS, INC. 2024-01-18 US disclosed
WO-2023177629-A1 POLYMER NANOAGGREGATE PHARMACEUTICAL COMPOSITION AND USE THEREOF ANP TECHNOLOGIES, INC. (US) 2023-09-21 WO disclosed
WO-2023178038-A1 NANOENCAPSULATED PHARMACEUTICAL COMPOSITION AND USE THEREOF FULGENT GENETICS, INC. (US) 2023-09-21 WO disclosed
US-20230190797-A1 COMPOSITIONS AND METHODS FOR ADOPTIVE CELL THERAPY MEMORIAL SLOAN KETTERING CANCER CENTER (US) 2023-06-22 US disclosed
EP-3925625-A1 HYDROPHOBIC MOLECULE-INDUCED BRANCHED POLYMER AGGREGATES AND THEIR USE ANP Technologies, Inc. (US) 2021-12-22 EP disclosed
WO-2021046497-A2 ORALLY DELIVERED THERAPEUTICAL COMPOSITION AND USE THEREOF SHEN HAIFA (US) 2021-03-11 WO disclosed
EP-2661281-B1 HYDROPHOBIC MOLECULE-INDUCED BRANCHED POLYMER AGGREGATES AND THEIR USE ANP TECH INC (US) 2021-03-10 EP disclosed
US-20210059939-A1 Hydrophobic Molecule-Induced Branched Polymer Aggregates and their Use FULGENT GENETICS, INC. 2021-03-04 US disclosed
US-20200392289-A1 Biodegradable Polymer and Use Thereof FULGENT GENETICS, INC. 2020-12-17 US disclosed
WO-1999040787-A1 MODIFIED PHARMACOLOGICALLY ACTIVE AGENTS AND IMPROVED THERAPEUTIC METHODS EMPLOYING SAME MEDINOX, INC. (US) 1999-08-19 WO disclosed
WO-1999040907-A1 METHODS FOR THE CONTROLLED DELIVERY OF CARBON DISULFIDE FOR THE TREATMENT OF INFLAMMATORY CONDITIONS MEDINOX, INC. (US) 1999-08-19 WO disclosed
US-5916910-A Conjugates of dithiocarbamates with pharmacologically active agents and uses therefore MEDINOX, INC. (US) 1999-06-29 US disclosed
US-5916596-A WATER INSOLUBLE DRUGS AND DRUG DELIVERY VIVORX PHARMACEUTICALS, INC. (US) 1999-06-29 US disclosed
WO-1999000113-A9 NOVEL FORMULATIONS OF PHARMACOLOGICAL AGENTS, METHODS FOR THE PREPARATION THEREOF AND METHODS FOR THE USE THEREOF VIVORX PHARMACEUTICALS INC (US) 1999-04-08 WO disclosed
US-5875776-A Dry powder inhaler VIVORX PHARMACEUTICALS, INC. (US) 1999-03-02 US disclosed
WO-1999000113-A1 NOVEL FORMULATIONS OF PHARMACOLOGICAL AGENTS, METHODS FOR THE PREPARATION THEREOF AND METHODS FOR THE USE THEREOF VIVORX PHARMACEUTICALS, INC. (US) 1999-01-07 WO disclosed
WO-1998055453-A1 CONJUGATES OF DITHIOCARBAMATES WITH PHARMACOLOGICALLY ACTIVE AGENTS AND USES THEREFOR MEDINOX, INC. (US) 1998-12-10 WO disclosed
WO-1998014174-A1 PROTEIN STABILIZED PHARMACOLOGICALLY ACTIVE AGENTS, METHODS FOR THE PREPARATION THEREOF AND METHODS FOR THE USE THEREOF VIVORX PHARMACEUTICALS, INC. (US) 1998-04-09 WO disclosed
WO-1997037708-A1 DRY POWDER INHALER VIVORX PHARMACEUTICALS, INC. (US) 1997-10-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200392289-A1 Biodegradable Polymer and Use Thereof PBK, PUF60, CD47 NR3C1 4217/4885HIF1A 2315/4885LMNA 692/4885
US-20230190797-A1 COMPOSITIONS AND METHODS FOR ADOPTIVE CELL THERAPY HAVCR2, CD4, CCR1 NR3C1 1611/4885HIF1A 721/4885LMNA 3918/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.