Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 4/20 | 0.58 |
| ▸ | BCHE | P06276 | 3/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | PI4KA | P42356 | 1/20 | 0.38 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.38 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8968656 | 0.99 | ACHE (0.60) | ACHEBCHEGRIN1GRIN2AMAPT | |
| SCHEMBL8969172 | 0.80 | ACHE (0.54) | ACHEBCHEMAPTLMNATHRB | |
| SCHEMBL8968353 | 0.79 | ACHE (0.56) | ACHEMAPTLMNATHRBSMN1; SMN2 | |
| SCHEMBL8969210 | 0.77 | ACHE (0.58) | ACHEMAPTLMNATHRBSMN1; SMN2 | |
| SCHEMBL8969679 | 0.77 | ACHE (0.78) | ACHEBCHEGRIN1GRIN2AMAPT | |
| SCHEMBL8969554 | 0.77 | ACHE (0.61) | ACHELMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL8969447 | 0.77 | ACHE (0.68) | ACHELMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL8968881 | 0.76 | ACHE (0.80) | ACHEBCHEGRIN1GRIN2AMAPT | |
| SCHEMBL8968510 | 0.76 | ACHE (0.60) | ACHEMAPTLMNATHRBSMN1; SMN2 | |
| SCHEMBL8968470 | 0.76 | ACHE (0.64) | ACHEMAPTLMNASMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5486512-A | LEARNING ENHANCEMENT | WARNER-LAMBERT COMPANY (US) | 1996-01-23 | — | — | US | disclosed |
| WO-1993003034-A1 | QUINAZOLINE DERIVATIVES AS ACETYLCHOLINESTERASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1993-02-18 | — | — | WO | disclosed |