Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8969322 | 1.00 | MGAM (0.48) | MGAMMAPTESR1ESR2NR1H2 | |
| SCHEMBL9773556 | 0.79 | ESR1 (0.42) | MGAMMAPTESR1ESR2NR1H2 | |
| SCHEMBL9773554 | 0.79 | ESR1 (0.42) | MGAMMAPTESR1ESR2NR1H2 | |
| SCHEMBL9773562 | 0.79 | ESR1 (0.42) | MGAMMAPTESR1ESR2NR1H2 | |
| SCHEMBL8718382 | 0.79 | MGAM (0.42) | MGAMMAPTESR1ESR2 | |
| SCHEMBL7986098 | 0.78 | TSHR (0.33) | MGAMMAPTESR1ESR2RECQL | |
| SCHEMBL5338829 | 0.78 | MGAM (0.40) | MGAMMAPTESR1ESR2NR1H2 | |
| SCHEMBL29945596 | 0.76 | MGAM (0.40) | MGAMMAPTESR1ESR2 | |
| SCHEMBL7030777 | 0.75 | KDM4E (0.37) | MAPTKDM4E | |
| SCHEMBL9219897 | 0.75 | MGAM (0.39) | MGAMTSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5536732-A | REDUCING INFECTIOUSNESS OF HIV | MERRELL PHARMACEUTICALS INC. (US) | 1996-07-16 | — | — | US | disclosed |
| US-5252587-A | Viricides, aids therapy, antidiabetic agent | MERRELL DOW PHARMACEUTICALS, INC. (US) | 1993-10-12 | — | — | US | disclosed |