SCHEMBL8969347

SCHEMBL8969347

C=CCOc1ccc(COCOCC)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.46
POLB P06746 2/20 0.46
MAPT P10636 2/20 0.46
NPC1 O15118 2/20 0.46
RAB9A P51151 2/20 0.46
ALDH1A1 P00352 5/20 0.43
USP2 O75604 1/20 0.43
CACNA1B Q00975 1/20 0.43
APBA1 Q02410 1/20 0.43
CA12 O43570 1/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
CA7 P43166 1/20 0.41
CA9 Q16790 1/20 0.41
BCHE P06276 3/20 0.40
CHRNB2 P17787 1/20 0.40
CHRNB4 P30926 1/20 0.40
CHRNA3 P32297 1/20 0.40
CHRNA4 P43681 1/20 0.40
TP53 P04637 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23906770 0.78 TSHR (0.42) CA1CA2CA9TSHRKDM4E
SCHEMBL9442490 0.77 NQO1 (0.45) SMN1; SMN2POLBMAPTNPC1RAB9A
SCHEMBL8423074 0.77 ALDH1A1 (0.43) SMN1; SMN2POLBMAPTNPC1RAB9A
SCHEMBL7929787 0.77 ALDH1A1 (0.50) SMN1; SMN2POLBMAPTNPC1RAB9A
1-Allyloxy-4-Ethoxybenzene SCHEMBL2846327 0.77 NQO1 (0.64) SMN1; SMN2POLBMAPTNPC1RAB9A
1,4-Diallyloxybenzene SCHEMBL302448 0.74 CA12 (0.63) SMN1; SMN2POLBMAPTNPC1RAB9A
SCHEMBL16923166 0.74 CA12 (0.47) SMN1; SMN2POLBMAPTNPC1RAB9A
SCHEMBL3627757 0.74 THRB (0.54) SMN1; SMN2POLBMAPTNPC1RAB9A
SCHEMBL19844431 0.73 CA12 (0.50) SMN1; SMN2POLBMAPTNPC1RAB9A
SCHEMBL8421683 0.73 FFAR1 (0.49) SMN1; SMN2POLBMAPTNPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0696284-A1 HETEROCYCLIC DERIVATIVES ZENECA LIMITED (GB) 1996-02-14 EP disclosed