Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 13/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8970444 | 0.82 | ACHE (0.70) | ACHEKDM4EALDH1A1LMNAHTT | |
| SCHEMBL8969901 | 0.79 | ACHE (0.69) | ACHEKDM4EALDH1A1HTTNPC1 | |
| SCHEMBL8968453 | 0.74 | ACHE (1.00) | ACHEALDH1A1LMNADRD2DRD4 | |
| SCHEMBL8968773 | 0.72 | ACHE (0.97) | ACHEALDH1A1LMNADRD2DRD4 | |
| SCHEMBL8968422 | 0.71 | ACHE (1.00) | ACHEALDH1A1LMNA | |
| SCHEMBL8969321 | 0.70 | ACHE (0.97) | ACHEALDH1A1LMNA | |
| SCHEMBL8969190 | 0.68 | ACHE (0.89) | ACHEALDH1A1LMNADRD2DRD4 | |
| SCHEMBL9382116 | 0.67 | ACHE (0.52) | ACHEKDM4EALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL24330116 | 0.66 | ACHE (0.67) | ACHEKDM4EALDH1A1LMNAHTT | |
| SCHEMBL9381904 | 0.66 | ACHE (0.51) | ACHEKDM4EALDH1A1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5486512-A | LEARNING ENHANCEMENT | WARNER-LAMBERT COMPANY (US) | 1996-01-23 | — | — | US | disclosed |
| EP-0597956-A1 | QUINAZOLINE DERIVATIVES AS ACETYLCHOLINESTERASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1994-05-25 | — | — | EP | disclosed |
| WO-1993003034-A1 | QUINAZOLINE DERIVATIVES AS ACETYLCHOLINESTERASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1993-02-18 | — | — | WO | disclosed |