Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 11/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | PRKCA | P17252 | 2/20 | 0.46 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.46 |
| ▸ | CASP1 | P29466 | 2/20 | 0.43 |
| ▸ | CASP5 | P51878 | 2/20 | 0.43 |
| ▸ | CASP4 | P49662 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9008398 | 0.89 | PRKCQ (0.50) | PRKCQHRH3PRKCAPRKCDCASP1 | |
| SCHEMBL8970038 | 0.87 | PRKCQ (0.56) | PRKCQPRKCAPRKCD | |
| SCHEMBL8970304 | 0.85 | PRKCQ (0.69) | PRKCQHRH3PRKCAPRKCD | |
| SCHEMBL8970237 | 0.85 | PRKCQ (0.58) | PRKCQPRKCAPRKCDHSD11B1 | |
| SCHEMBL11993693 | 0.83 | PRKCQ (0.52) | PRKCQPRKCAPRKCD | |
| SCHEMBL13857136 | 0.81 | PRKCQ (0.56) | PRKCQHRH3PRKCAPRKCDCASP1 | |
| SCHEMBL8970022 | 0.81 | PRKCQ (0.51) | PRKCQHRH3PRKCAPRKCDCASP1 | |
| SCHEMBL8969935 | 0.80 | PRKCQ (0.54) | PRKCQHRH3PRKCAPRKCD | |
| SCHEMBL11993696 | 0.80 | PRKCQ (0.49) | PRKCQPRKCAPRKCDALDH1A1 | |
| SCHEMBL8185355 | 0.79 | PRKCQ (0.71) | PRKCQPRKCAPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188071-B2 | Amino substituted pyridines as potent kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-05-29 | — | — | US | disclosed |