Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 16/20 | 0.55 |
| ▸ | PRKCA | P17252 | 2/20 | 0.53 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.47 |
| ▸ | HSD17B14 | Q9BPX1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9008587 | 0.90 | PRKCQ (0.68) | PRKCQPRKCAPRKCD | |
| SCHEMBL8965113 | 0.84 | PRKCQ (0.55) | PRKCQPRKCAPRKCDHSD11B1HSD17B14 | |
| SCHEMBL8970438 | 0.84 | PRKCQ (0.55) | PRKCQPRKCAPRKCDHSD11B1HSD17B14 | |
| SCHEMBL8970237 | 0.84 | PRKCQ (0.58) | PRKCQPRKCAPRKCDHSD11B1HSD17B14 | |
| SCHEMBL8969734 | 0.84 | PRKCQ (0.55) | PRKCQPRKCAPRKCDHSD11B1HSD17B14 | |
| SCHEMBL8970354 | 0.83 | PRKCQ (0.53) | PRKCQPRKCAPRKCDHSD11B1HSD17B14 | |
| SCHEMBL8970308 | 0.82 | PRKCQ (0.52) | PRKCQPRKCAPRKCDHSD11B1HSD17B14 | |
| SCHEMBL8969820 | 0.82 | PRKCQ (0.53) | PRKCQPRKCAPRKCDHSD11B1HSD17B14 | |
| SCHEMBL8970009 | 0.81 | PRKCQ (0.55) | PRKCQPRKCAPRKCDHSD11B1HSD17B14 | |
| SCHEMBL8970017 | 0.81 | PRKCQ (0.55) | PRKCQPRKCAPRKCDHSD11B1HSD17B14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188071-B2 | Amino substituted pyridines as potent kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-05-29 | — | — | US | disclosed |