Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 19/20 | 0.56 |
| ▸ | PRKCA | P17252 | 4/20 | 0.53 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11993705 | 1.00 | PRKCQ (0.56) | PRKCQPRKCAPRKCDMEN1CYP1A2 | |
| SCHEMBL8965670 | 0.89 | PRKCQ (0.70) | PRKCQPRKCAPRKCD | |
| SCHEMBL8965751 | 0.89 | PRKCQ (0.67) | PRKCQPRKCAPRKCD | |
| SCHEMBL8970446 | 0.86 | PRKCQ (0.53) | PRKCQPRKCAPRKCD | |
| SCHEMBL11993698 | 0.80 | PRKCQ (0.79) | PRKCQPRKCAPRKCD | |
| SCHEMBL11993703 | 0.79 | PRKCQ (0.56) | PRKCQPRKCAPRKCD | |
| SCHEMBL8970504 | 0.79 | PRKCQ (0.56) | PRKCQPRKCAPRKCD | |
| SCHEMBL8970209 | 0.78 | PRKCQ (0.62) | PRKCQPRKCAPRKCD | |
| SCHEMBL8965800 | 0.76 | PRKCQ (0.70) | PRKCQPRKCAPRKCD | |
| SCHEMBL8970165 | 0.72 | PRKCQ (1.00) | PRKCQPRKCAPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188071-B2 | Amino substituted pyridines as potent kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-05-29 | — | — | US | disclosed |