Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.59 |
| ▸ | HTR1D | P28221 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD5 | P21918 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7858439 | 0.91 | HTR1A (0.57) | HTR1AHTR1DACHE | |
| SCHEMBL8970224 | 0.91 | HTR1A (0.72) | HTR1AHTR1DDRD2DRD4DRD5 | |
| Hydrochloric Acid SCHEMBL8475126 | 0.91 | HTR1A (0.56) | HTR1AHTR1DACHE | |
| SCHEMBL8971009 | 0.89 | HTR1A (0.61) | HTR1ADRD2DRD4DRD5DRD3 | |
| Oxalic Acid SCHEMBL8472725 | 0.89 | HTR1A (0.54) | HTR1AHTR1DDRD2DRD4DRD5 | |
| SCHEMBL7837327 | 0.84 | HTR1A (0.81) | HTR1AHTR1D | |
| SCHEMBL8996726 | 0.84 | HTR1A (0.49) | HTR1ADRD2DRD4DRD5DRD3 | |
| Hydrochloric Acid SCHEMBL7841791 | 0.84 | HTR1A (0.80) | HTR1AHTR1D | |
| SCHEMBL9380662 | 0.84 | HTR1A (0.59) | HTR1AHTR1DDRD2DRD4DRD5 | |
| SCHEMBL9385765 | 0.83 | HTR1A (0.51) | HTR1AHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5506246-A | Method for treating depression using substituted aminomethyltetralins and their heterocyclic analogues | BAYER AKTIENGESELLSCHAFT (DE) | 1996-04-09 | — | — | US | claimed |
| EP-0352613-B1 | Substituted amino methyl tetralines, and their heterocyclic analogous compounds | BAYER AG (DE) | 1994-04-20 | — | — | EP | claimed |
| EP-0545120-A2 | Combination of 5-HT2-receptor antagonists and 5-HT1A-receptor agonists with neuroprotective effect | Troponwerke GmbH & Co. KG (DE) | 1993-06-09 | — | — | EP | claimed |
| US-5137901-A | For binding 5-HT 1 receptors; treating central nervous system disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1992-08-11 | — | — | US | claimed |
| US-5585392-A | TREATING OR PREVENTING STROKES | BAYER AKTIENGESELLSCHAFT (DE) | 1996-12-17 | — | — | US | disclosed |
| US-5506246-A | Method for treating depression using substituted aminomethyltetralins and their heterocyclic analogues | BAYER AKTIENGESELLSCHAFT (DE) | 1996-04-09 | — | — | US | disclosed |
| EP-0352613-B1 | Substituted amino methyl tetralines, and their heterocyclic analogous compounds | BAYER AG (DE) | 1994-04-20 | — | — | EP | disclosed |
| US-5300523-A | Binding serotonin receptors, treating nervous system disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1994-04-05 | — | — | US | disclosed |
| EP-0545120-A2 | Combination of 5-HT2-receptor antagonists and 5-HT1A-receptor agonists with neuroprotective effect | Troponwerke GmbH & Co. KG (DE) | 1993-06-09 | — | — | EP | disclosed |
| US-5137901-A | For binding 5-HT 1 receptors; treating central nervous system disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1992-08-11 | — | — | US | disclosed |
| EP-0352613-A2 | Substituted amino methyl tetralines, and their heterocyclic analogous compounds | BAYER AG (DE) | 1990-01-31 | — | — | EP | disclosed |