Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 4/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD5 | P21918 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8971218 | 0.91 | HTR1A (0.59) | HTR1ADRD2DRD4DRD5DRD3 | |
| SCHEMBL8970394 | 0.85 | HTR1A (0.45) | HTR1ACHRM2CHRM1CHRM3DRD2 | |
| SCHEMBL8970453 | 0.84 | HTR1A (0.59) | HTR1ADRD2DRD4DRD5DRD3 | |
| SCHEMBL9286203 | 0.84 | HTR1A (0.54) | HTR1ADRD2DRD4DRD5DRD3 | |
| SCHEMBL8970658 | 0.84 | MTNR1A (0.39) | HTR1ACHRM2CHRM1CHRM3DRD2 | |
| SCHEMBL8971009 | 0.82 | HTR1A (0.61) | HTR1ADRD2DRD4DRD5DRD3 | |
| SCHEMBL9382677 | 0.82 | ADRA1D (0.42) | HTR1ACHRM2CHRM1CHRM3DRD2 | |
| SCHEMBL9382674 | 0.80 | CHRM2 (0.45) | HTR1ACHRM2CHRM1CHRM3DRD2 | |
| SCHEMBL8970653 | 0.79 | HTR1A (0.41) | HTR1ACHRM2CHRM1CHRM3DRD2 | |
| SCHEMBL8969531 | 0.79 | HTR7 (0.55) | HTR1ACHRM2CHRM1CHRM3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5585392-A | TREATING OR PREVENTING STROKES | BAYER AKTIENGESELLSCHAFT (DE) | 1996-12-17 | — | — | US | disclosed |
| EP-0352613-B1 | Substituted amino methyl tetralines, and their heterocyclic analogous compounds | BAYER AG (DE) | 1994-04-20 | — | — | EP | disclosed |
| US-5300523-A | Binding serotonin receptors, treating nervous system disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1994-04-05 | — | — | US | disclosed |
| US-5137901-A | For binding 5-HT 1 receptors; treating central nervous system disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1992-08-11 | — | — | US | disclosed |
| EP-0352613-A2 | Substituted amino methyl tetralines, and their heterocyclic analogous compounds | BAYER AG (DE) | 1990-01-31 | — | — | EP | disclosed |