SCHEMBL8970856

SCHEMBL8970856

COC(=O)/C(Cl)=C(/C)OC

nearest known ligand 0.43

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.43
MGAM O43451 1/20 0.32
GAA P10253 1/20 0.32
SI P14410 1/20 0.32
MGAM2 Q2M2H8 1/20 0.32
MAPT P10636 1/20 0.31
TET2 Q6N021 1/20 0.31
EGLN1 Q9GZT9 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9321081 1.00 ALDH1A1 (0.43) ALDH1A1MGAMGAASIMGAM2
SCHEMBL9720623 0.82 ALDH1A1 (0.45) ALDH1A1MGAMGAASIMGAM2
SCHEMBL9720619 0.82 ALDH1A1 (0.45) ALDH1A1MGAMGAASIMGAM2
SCHEMBL11145544 0.82 ALDH1A1 (0.45) ALDH1A1MGAMGAASIMGAM2
SCHEMBL9816050 0.80
SCHEMBL9816047 0.80
SCHEMBL8571994 0.80
SCHEMBL5073859 0.78
SCHEMBL11147133 0.78 ALDH1A1 (0.43) ALDH1A1MGAMGAASIMGAM2
SCHEMBL5073856 0.78

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0529483-B1 Process for the preparation of optically active 4-amino-3-hydroxycarboxylic acids LONZA AG (CH) 1996-02-28 EP disclosed
US-5352801-A Process for the production of optically-active 4-amino-3-hydroxycarboxylic acids LONZA LTD. (CH) 1994-10-04 US disclosed
US-5286650-A Process for the production of optically-active 4-amino-3-hydroxycarboxylic acids LONZA LTD. (CH) 1994-02-15 US disclosed
EP-0529483-A2 Process for the preparation of optically active 4-amino-3-hydroxycarboxylic acids LONZA AG (CH) 1993-03-03 EP disclosed