Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.56 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | TDO2 | P48775 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7218237 | 0.85 | MAPT (0.74) | MAPTALDH1A1L3MBTL1KDM4ENLRP3 | |
| SCHEMBL27619302 | 0.77 | ALDH1A1 (0.62) | MAPTALDH1A1L3MBTL1KDM4ENLRP3 | |
| SCHEMBL6297845 | 0.75 | MAPT (0.59) | MAPTALDH1A1L3MBTL1KDM4ENLRP3 | |
| SCHEMBL14364502 | 0.74 | ALDH1A1 (0.59) | MAPTALDH1A1L3MBTL1KDM4ENLRP3 | |
| SCHEMBL28573090 | 0.74 | MAPT (0.59) | MAPTALDH1A1L3MBTL1KDM4EMEN1 | |
| SCHEMBL7681777 | 0.74 | MAPT (0.58) | MAPTALDH1A1L3MBTL1KDM4ENLRP3 | |
| SCHEMBL16349772 | 0.73 | ALDH1A1 (0.58) | MAPTALDH1A1L3MBTL1KDM4ENLRP3 | |
| SCHEMBL1461839 | 0.73 | MAPT (0.56) | MAPTALDH1A1L3MBTL1KDM4ENLRP3 | |
| SCHEMBL8999062 | 0.72 | MAPT (0.56) | MAPTALDH1A1L3MBTL1KDM4EGAA | |
| SCHEMBL7093706 | 0.72 | MAPT (0.55) | MAPTALDH1A1L3MBTL1KDM4ENLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5580877-A | Pyrazolo-quinoline derivatives for treating cerebral ischemia | MERCK SHARP & DOHME LTD. (GB) | 1996-12-03 | — | — | US | disclosed |