Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 13/20 | 0.76 |
| ▸ | NOS2 | P35228 | 4/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | TDO2 | P48775 | 1/20 | 0.46 |
| ▸ | OGG1 | O15527 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7050433 | 0.86 | SLC6A4 (1.00) | SLC6A4NOS2CYP2D6SLC6A2KCNH2 | |
| SCHEMBL8971677 | 0.85 | SLC6A4 (0.70) | SLC6A4CYP2D6SLC6A2KCNH2DRD2 | |
| SCHEMBL7050753 | 0.84 | SLC6A4 (0.68) | SLC6A4NOS2IDO1TDO2CYP2D6 | |
| Oxalic Acid SCHEMBL7319549 | 0.80 | SLC6A4 (0.62) | SLC6A4NOS2IDO1TDO2OGG1 | |
| SCHEMBL14415642 | 0.77 | SLC6A4 (0.58) | SLC6A4NOS2IDO1TDO2OGG1 | |
| SCHEMBL14415641 | 0.75 | SLC6A4 (0.57) | SLC6A4NOS2IDO1TDO2CYP2D6 | |
| SCHEMBL8971244 | 0.75 | NOS2 (0.56) | SLC6A4NOS2CYP2D6SLC6A2KCNH2 | |
| SCHEMBL21391835 | 0.75 | SLC6A4 (0.60) | SLC6A4OGG1CYP2D6SLC6A2 | |
| SCHEMBL18228719 | 0.75 | SLC6A4 (0.60) | SLC6A4OGG1CYP2D6SLC6A2 | |
| SCHEMBL18228682 | 0.75 | SLC6A4 (0.60) | SLC6A4OGG1CYP2D6SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0545425-B1 | 2-(3-Phenylpropyl)hydrazines, intermediates in and a process for the preparation thereof, and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1996-03-20 | — | — | EP | disclosed |
| US-5268468-A | Or optical isomers thereof | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-12-07 | — | — | US | disclosed |
| US-5229417-A | Obsessive compulsive disorders | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-07-20 | — | — | US | disclosed |
| EP-0545425-A1 | 2-(3-Phenylpropyl)hydrazines, intermediates in and a process for the preparation thereof, and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-06-09 | — | — | EP | disclosed |