Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 14/20 | 0.56 |
| ▸ | DRD2 | P14416 | 4/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | GMNN | O75496 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9091624 | 0.94 | SIGMAR1 (0.61) | SIGMAR1DRD2GMNNTP53CYP3A4 | |
| SCHEMBL8970673 | 0.94 | SIGMAR1 (0.52) | SIGMAR1DRD2SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL8970816 | 0.93 | SIGMAR1 (0.60) | SIGMAR1DRD2GMNNTP53CYP3A4 | |
| SCHEMBL8970920 | 0.93 | SIGMAR1 (0.60) | SIGMAR1DRD2GMNNTP53CYP3A4 | |
| SCHEMBL8971631 | 0.90 | SLC6A4 (0.56) | SIGMAR1SLC6A4SLC6A2SLC6A3MAPK1 | |
| SCHEMBL8971041 | 0.90 | SLC6A4 (0.59) | SIGMAR1SLC6A4SLC6A2SLC6A3ALOX15 | |
| Hydrochloric Acid SCHEMBL8970739 | 0.89 | SLC6A4 (0.55) | SIGMAR1SLC6A4SLC6A2SLC6A3MAPK1 | |
| SCHEMBL8970731 | 0.89 | SLC6A4 (0.57) | SIGMAR1SLC6A4SLC6A2SLC6A3ALOX15 | |
| SCHEMBL9093201 | 0.89 | DRD2 (0.64) | SIGMAR1DRD2DRD3LMNA | |
| SCHEMBL9092055 | 0.89 | SIGMAR1 (0.56) | SIGMAR1DRD2SLC6A4SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0490560-B1 | 1,2,3,6-Tetrahydropyridine derivatives | RICHTER GEDEON VEGYESZET (HU) | 1996-03-20 | — | — | EP | claimed |
| EP-0490560-B1 | 1,2,3,6-Tetrahydropyridine derivatives | RICHTER GEDEON VEGYESZET (HU) | 1996-03-20 | — | — | EP | disclosed |
| US-5225416-A | 1,2,3,6-TETRAHYDROPYRIDINE DERIVATIVES USEFUL FOR IMPROVING CEREBRAL BLOOD CIRCULATION | RICHTER GEDEON VEGYESZETI TERMEKEK GYARA RT. (HU) | 1993-07-06 | — | — | US | disclosed |
| EP-0490560-A1 | 1,2,3,6-Tetrahydropyridine derivatives | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1992-06-17 | — | — | EP | disclosed |