Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 4/20 | 0.60 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.60 |
| ▸ | GPR4 | P46093 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| L-158809 SCHEMBL683357 | 0.92 | AGTR2 (0.71) | AGTR2AGTR1GPR4 | |
| L-158809 SCHEMBL7944169 | 0.91 | AGTR2 (0.70) | AGTR2AGTR1GPR4 | |
| SCHEMBL2774605 | 0.89 | AGTR2 (0.58) | AGTR2AGTR1 | |
| SCHEMBL7941438 | 0.87 | AGTR1 (0.56) | AGTR2AGTR1 | |
| SCHEMBL9054272 | 0.86 | AGTR2 (0.55) | AGTR2AGTR1 | |
| SCHEMBL8567083 | 0.86 | AGTR1 (0.61) | AGTR2AGTR1 | |
| SCHEMBL8972219 | 0.84 | AGTR1 (0.72) | AGTR2AGTR1 | |
| SCHEMBL9406686 | 0.83 | AGTR1 (0.73) | AGTR2AGTR1 | |
| SCHEMBL8741166 | 0.83 | AGTR2 (0.61) | AGTR2AGTR1GPR4 | |
| SCHEMBL9655735 | 0.81 | AGTR2 (0.57) | AGTR2AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5506238-A | HYPOTENSIVE AGENT | EISAI CO., LTD. (JP) | 1996-04-09 | — | — | US | disclosed |
| EP-0628557-A1 | Biphenylmethane derivatives, the use of them and pharmacological compositions containing same | Eisai Co., Ltd. (JP) | 1994-12-14 | — | — | EP | disclosed |
| US-5328911-A | Cardiovascular disorders, hypotensive agents and congestive heart failure | EISAI CO., LTD. (JP) | 1994-07-12 | — | — | US | disclosed |
| EP-0598702-A1 | Biphenylmethane derivative, the use of it and pharmacological compositions containing same | Eisai Co., Ltd. (JP) | 1994-05-25 | — | — | EP | disclosed |
| US-5298518-A | Biphenylmethane derivative and pharmacological use | EISAI CO., LTD. (JP) | 1994-03-29 | — | — | US | disclosed |
| EP-0420237-A1 | Biphenylmethane derivative, the use of it and pharmacological compositions containing same | Eisai Co., Ltd. (JP) | 1991-04-03 | — | — | EP | disclosed |