Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 2/20 | 0.59 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8971815 | 0.97 | AGTR1 (0.57) | AGTR1AGTR2ALDH1A1MEN1KMT2A | |
| SCHEMBL8972529 | 0.90 | AGTR1 (0.62) | AGTR1AGTR2 | |
| SCHEMBL7622112 | 0.88 | AGTR1 (0.72) | AGTR1AGTR2 | |
| SCHEMBL29486817 | 0.88 | AGTR1 (0.72) | AGTR1AGTR2 | |
| SCHEMBL9851416 | 0.88 | AGTR1 (0.61) | AGTR1AGTR2LMNA | |
| Hydrochloric Acid SCHEMBL7841670 | 0.88 | AGTR1 (0.71) | AGTR1AGTR2 | |
| SCHEMBL8972164 | 0.86 | AGTR1 (0.60) | AGTR1AGTR2ALDH1A1 | |
| SCHEMBL9312828 | 0.86 | AGTR1 (0.68) | AGTR1AGTR2 | |
| SCHEMBL8971991 | 0.85 | AGTR1 (0.56) | AGTR1AGTR2 | |
| SCHEMBL8972687 | 0.84 | AGTR1 (0.61) | AGTR1AGTR2MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5506238-A | HYPOTENSIVE AGENT | EISAI CO., LTD. (JP) | 1996-04-09 | — | — | US | disclosed |
| EP-0628557-A1 | Biphenylmethane derivatives, the use of them and pharmacological compositions containing same | Eisai Co., Ltd. (JP) | 1994-12-14 | — | — | EP | disclosed |
| EP-0598702-A1 | Biphenylmethane derivative, the use of it and pharmacological compositions containing same | Eisai Co., Ltd. (JP) | 1994-05-25 | — | — | EP | disclosed |
| US-5298518-A | Biphenylmethane derivative and pharmacological use | EISAI CO., LTD. (JP) | 1994-03-29 | — | — | US | disclosed |