Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 5/20 | 0.72 |
| ▸ | AGTR2 | P50052 | 5/20 | 0.72 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29486817 | 1.00 | AGTR1 (0.72) | AGTR1AGTR2ENPP2 | |
| Hydrochloric Acid SCHEMBL7841670 | 0.99 | AGTR1 (0.71) | AGTR1AGTR2ENPP2 | |
| SCHEMBL9312828 | 0.97 | AGTR1 (0.68) | AGTR1AGTR2ENPP2 | |
| SCHEMBL8972057 | 0.94 | AGTR1 (0.71) | AGTR1AGTR2 | |
| SCHEMBL8972068 | 0.91 | AGTR1 (0.60) | AGTR1AGTR2 | |
| SCHEMBL8972164 | 0.91 | AGTR1 (0.60) | AGTR1AGTR2ENPP2 | |
| SCHEMBL8972529 | 0.91 | AGTR1 (0.62) | AGTR1AGTR2ENPP2 | |
| SCHEMBL9851416 | 0.90 | AGTR1 (0.61) | AGTR1AGTR2ENPP2 | |
| SCHEMBL9853668 | 0.89 | AGTR1 (0.57) | AGTR1AGTR2 | |
| SCHEMBL9851484 | 0.89 | AGTR1 (0.56) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6448280-B1 | SUCH AS 2-BUTYL-4-CHLORO-5-HYDROXYMETHYL-1-((2'-(1H-TETRAZOL-5-YL) IPHENYL-4-YL)ME THYL)IMIDAZOLE; | ZENECA LIMITED (GB) | 2002-09-10 | — | — | US | claimed |
| EP-0636027-A1 | ANGIOTENSIN II ANTAGONISTS AGAINST DISORDERS ASSOCIATED WITH IMPAIRED NEURONAL CONDUCTION VELOCITY, ESPECIALLY DIABETIC NEUROPATHY | ZENECA LIMITED (GB) | 1995-02-01 | — | — | EP | claimed |
| US-5334718-A | Decyclizing a phenyl or a pyridyl or pyrimidyl group by reacting with a base to get angiotension antagonist | ZENECA LIMITED (GB) | 1994-08-02 | — | — | US | claimed |
| EP-0399731-B1 | Azaindenes | ZENECA LTD (GB) | 1993-12-08 | — | — | EP | claimed |
| WO-1993020816-A1 | ANGIOTENSIN II ANTAGONISTS AGAINST DISORDERS ASSOCIATED WITH IMPAIRED NEURONAL CONDUCTION VELOCITY, ESPECIALLY DIABETIC NEUROPATHY | ZENECA LIMITED (GB) | 1993-10-28 | — | — | WO | claimed |
| EP-0554098-A2 | Process for the preparation of imidazo 4,5-b pyridine derivatives | ZENECA LIMITED (GB) | 1993-08-04 | — | — | EP | claimed |
| EP-0434038-A1 | Fused imidazole derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-06-26 | — | — | EP | claimed |
| EP-0426021-A1 | Condensed imidazole derivatives and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-05-08 | — | — | EP | claimed |
| EP-0415886-A2 | Aza compounds | CIBA-GEIGY AG (CH) | 1991-03-06 | — | — | EP | claimed |
| JP-3005480-A | — | — | None | — | — | JP | disclosed |
| JP-3188076-A | — | — | None | — | — | JP | disclosed |
| US-6448280-B1 | SUCH AS 2-BUTYL-4-CHLORO-5-HYDROXYMETHYL-1-((2'-(1H-TETRAZOL-5-YL) IPHENYL-4-YL)ME THYL)IMIDAZOLE; | ZENECA LIMITED (GB) | 2002-09-10 | — | — | US | disclosed |
| US-5661158-A | HYPOTENSIVE AGENTS, ANTICHOLESTEROL AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-08-26 | — | — | US | disclosed |
| US-5506238-A | HYPOTENSIVE AGENT | EISAI CO., LTD. (JP) | 1996-04-09 | — | — | US | disclosed |
| EP-0554098-A2 | Process for the preparation of imidazo 4,5-b pyridine derivatives | ZENECA LIMITED (GB) | 1993-08-04 | — | — | EP | disclosed |
| JP-H03188076-A | CONDENSED IMIDAZOLE DERIVATIVE AND PRODUCTION THEREOF | FUJISAWA PHARMACEUT CO LTD | 1991-08-16 | — | — | JP | disclosed |
| EP-0426021-A1 | Condensed imidazole derivatives and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-05-08 | — | — | EP | disclosed |
| EP-0420237-A1 | Biphenylmethane derivative, the use of it and pharmacological compositions containing same | Eisai Co., Ltd. (JP) | 1991-04-03 | — | — | EP | disclosed |
| EP-0415886-A2 | Aza compounds | CIBA-GEIGY AG (CH) | 1991-03-06 | — | — | EP | disclosed |
| JP-H035480-A | AZAINDENE, ITS PRODUCTION, THERAPEUTIC AGENT OF HYPERTENSION AND CONGESTIVE HEART DISEASE CONTAINING SUCH AZAINDENE AND INTERMEDIATE | IMPERIAL CHEM IND PLC <ICI> | 1991-01-11 | — | — | JP | disclosed |