Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5653522 | 1.00 | GLA (0.55) | GLAL3MBTL1RAB9AFKBP1ATSHR | |
| SCHEMBL12580731 | 0.93 | GLA (0.58) | GLAL3MBTL1RAB9AFKBP1ATSHR | |
| SCHEMBL8972662 | 0.88 | GNAI3 (0.51) | L3MBTL1LMNACYP3A4ALDH1A1USP2 | |
| SCHEMBL105393 | 0.86 | TSHR (0.53) | GLAL3MBTL1RAB9AFKBP1ATSHR | |
| SCHEMBL7694058 | 0.86 | GLA (0.65) | GLAL3MBTL1RAB9AFKBP1ATSHR | |
| SCHEMBL16604260 | 0.84 | L3MBTL1 (0.54) | GLAL3MBTL1RAB9AFKBP1ATSHR | |
| SCHEMBL5654305 | 0.84 | L3MBTL1 (0.61) | L3MBTL1ALDH1A1TDP1 | |
| SCHEMBL9415751 | 0.84 | GLA (0.67) | GLAL3MBTL1RAB9AFKBP1ATSHR | |
| SCHEMBL11543790 | 0.83 | GLA (0.49) | GLAL3MBTL1RAB9AFKBP1ATSHR | |
| SCHEMBL5652742 | 0.83 | L3MBTL1 (0.62) | L3MBTL1ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268222-B1 | Penetration enhancers for transdermal delivery of systemic agents | RES TRIANGLE PHARM LTD (US) | 1996-03-27 | — | — | EP | disclosed |
| EP-0582065-A1 | 1-Oxohydrocarbyl-substituted azacyclohexanes compositions used as acid catalyst | WHITBY RESEARCH, Inc. (US) | 1994-02-09 | — | — | EP | disclosed |
| EP-0280703-B1 | COMPOSITIONS COMPRISING 1-ACYL-SUBSTITUTED MORPHOLINES, THIOMORPHOLINES AND PIPERAZINES AND THEIR USES | WHITBY RESEARCH INC (US) | 1993-12-29 | — | — | EP | disclosed |
| US-5073544-A | Penetration promoters | WHITBY, INC. (US) | 1991-12-17 | — | — | US | disclosed |
| US-4917896-A | PIPERAZINE, MORPHOLINE OR THIOMORPHOLINE DERIVATIVE | NELSON RESEARCH & DEVELOPMENT CO. (US) | 1990-04-17 | — | — | US | disclosed |
| EP-0268222-A2 | Penetration enhancers for transdermal delivery of systemic agents | RESEARCH TRIANGLE PHARMACEUTICALS LTD. (US) | 1988-05-25 | — | — | EP | disclosed |