SCHEMBL8973147

SCHEMBL8973147

Cc1ccc(Nc2nc(Cl)nc(Cl)n2)cc1C

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NFKB1 P19838 4/20 0.62
KDM4E B2RXH2 2/20 0.53
L3MBTL1 Q9Y468 2/20 0.53
JAK2 O60674 1/20 0.53
GAA P10253 1/20 0.53
APP P05067 2/20 0.53
MAPT P10636 4/20 0.50
NPC1 O15118 2/20 0.50
KMT2A Q03164 2/20 0.50
TXN P10599 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
RAB9A P51151 1/20 0.50
TAAR1 Q96RJ0 1/20 0.50
TERT O14746 1/20 0.49
MEN1 O00255 1/20 0.48
MAPK1 P28482 1/20 0.48
POLB P06746 3/20 0.48
CA12 O43570 1/20 0.47
CA1 P00915 1/20 0.47
CA2 P00918 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8973537 0.87 NFKB1 (0.60) NFKB1KDM4EAPPMAPTNPC1
SCHEMBL10078028 0.86 MAPT (0.61) KDM4EL3MBTL1JAK2GAAMAPT
SCHEMBL14268288 0.84 NFKB1 (0.57) NFKB1KDM4EAPPMAPTNPC1
SCHEMBL5033983 0.84 APP (0.60) NFKB1KDM4EAPPMAPTNPC1
SCHEMBL19284139 0.84 NFKB1 (0.57) NFKB1KDM4EL3MBTL1JAK2GAA
SCHEMBL30345300 0.84 NFKB1 (0.57) NFKB1KDM4EL3MBTL1JAK2GAA
SCHEMBL11837292 0.80 NFKB1 (0.78) NFKB1KDM4EAPPMAPTNPC1
SCHEMBL23999250 0.79 MAPT (0.55) KDM4EL3MBTL1JAK2GAAMAPT
SCHEMBL6536659 0.79 NPC1 (0.72) NFKB1KDM4EJAK2APPMAPT
SCHEMBL9010627 0.78 NFKB1 (0.50) NFKB1KDM4EAPPMAPTNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5561131-A INCREASING THE WOOL GROWTH BY ADMINISTERING AN ANTIPROTOZOA AGENT TO SHEEP MALLINCKRODT VETERINARY, INC. (US) 1996-10-01 US claimed