Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA4 | P22748 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.45 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8799200 | 0.79 | ALOX15 (0.49) | ALOX15TSHRALDH1A1CA2CA12 | |
| SCHEMBL8799536 | 0.71 | CA1 (0.70) | ALDH1A1CA2CA12CA1CA4 | |
| SCHEMBL12257976 | 0.71 | PSMB8 (0.64) | ALOX15TSHRALDH1A1CA2CA12 | |
| SCHEMBL25938097 | 0.71 | NPC1 (0.63) | ALOX15TSHRALDH1A1MAPK1NPC1 | |
| SCHEMBL8800480 | 0.71 | NCEH1 (0.35) | ALOX15TSHRALDH1A1NPC1RAB9A | |
| SCHEMBL30179604 | 0.70 | PSMB8 (0.58) | ALDH1A1CA2CA12CA1CA4 | |
| SCHEMBL28332572 | 0.70 | PSMB8 (0.58) | ALDH1A1CA2CA12CA1CA4 | |
| Hydrochloric Acid SCHEMBL25332919 | 0.70 | NPC1 (0.62) | ALOX15TSHRALDH1A1MAPK1NPC1 | |
| SCHEMBL29572038 | 0.69 | PSMB8 (0.60) | ALOX15TSHRALDH1A1CA2CA12 | |
| SCHEMBL2128591 | 0.69 | PSMB8 (0.60) | ALOX15TSHRALDH1A1CA2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35279-E | ALDOSE REDUCTASE INHIBITORS | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| US-5202339-A | Hypoglycemic, hypolipedemic agents | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1993-04-13 | — | — | US | disclosed |
| US-5004751-A | Antidiabetic agents; aldoe reductase inhibitors | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1991-04-02 | — | — | US | disclosed |
| US-4914099-A | TREATMENT OR PREVENTION OF DIABETIC COMPLICATIONS | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1990-04-03 | — | — | US | disclosed |