SCHEMBL8973410

SCHEMBL8973410

Clc1nc(Cl)nc(Nc2cccc3ccccc23)n1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.65
MAPT P10636 6/20 0.55
RAB9A P51151 2/20 0.55
NPC1 O15118 1/20 0.55
NCOA1 Q15788 1/20 0.55
L3MBTL1 Q9Y468 1/20 0.55
NCOA3 Q9Y6Q9 1/20 0.55
ALDH1A1 P00352 3/20 0.53
HSD17B10 Q99714 2/20 0.53
HPGD P15428 2/20 0.53
NFKB1 P19838 2/20 0.53
TP53 P04637 1/20 0.53
CYP3A4 P08684 1/20 0.53
ALOX15 P16050 1/20 0.53
CDC25B P30305 1/20 0.53
ATM Q13315 1/20 0.53
FADS1 O60427 1/20 0.53
KMT2A Q03164 2/20 0.51
SMN1; SMN2 Q16637 2/20 0.51
KDM4E B2RXH2 2/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8973367 0.96 TSHR (0.59) TSHRMAPTRAB9ANPC1NCOA1
SCHEMBL11802348 0.89 MAPT (0.68) TSHRMAPTRAB9ANPC1NCOA1
SCHEMBL14511077 0.89 TSHR (0.51) TSHRMAPTRAB9ANPC1NCOA1
SCHEMBL24490451 0.86 HSD17B10 (0.63) TSHRMAPTRAB9ANPC1NCOA1
SCHEMBL11800267 0.85 TSHR (0.47) TSHRMAPTRAB9ANPC1NCOA1
SCHEMBL11800480 0.85 LMNA (0.54) TSHRMAPTRAB9ANPC1NCOA1
SCHEMBL11810122 0.85 POLB (0.56) TSHRMAPTRAB9ANPC1NCOA1
SCHEMBL11800333 0.85 MAPT (0.65) TSHRMAPTRAB9ANPC1NCOA1
SCHEMBL11837274 0.84 TSHR (0.80) TSHRMAPTRAB9ANPC1ALDH1A1
SCHEMBL6482620 0.83 ULK1 (0.49) TSHRMAPTRAB9ANPC1NCOA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020146779-A1 mTORC1 INHIBITORS FOR ACTIVATING AUTOPHAGY THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2020-07-16 WO disclosed
WO-2018175958-A1 THIOREDOXIN MODULATORS AND USES THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2018-09-27 WO disclosed
US-5561131-A INCREASING THE WOOL GROWTH BY ADMINISTERING AN ANTIPROTOZOA AGENT TO SHEEP MALLINCKRODT VETERINARY, INC. (US) 1996-10-01 US disclosed
EP-0661976-A1 DEFAUNATION METHOD MALLINCKRODT VETERINARY LIMITED (AU) 1995-07-12 EP disclosed
EP-0661976-A4 DEFAUNATION METHOD. MALLINCKRODT VETERINARY LTD (AU) 1994-07-20 EP disclosed
WO-1993002680-A1 DEFAUNATION METHOD PITMAN-MOORE AUSTRALIA LIMITED (AU) 1993-02-18 WO disclosed
US-3954702-A VULCANIZATION DEUTSCHE GOLD- UND SILBER-SCHEIDEANSTALT VORMALS ROESSLER (DT) 1976-05-04 US disclosed
US-3939158-A N-(2,4-dihalo-S-triazin-6-yl)-ureas and process for their manufacture CIBA-GEIGY AG (CH) 1976-02-17 US disclosed