Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 5/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 5/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | GMNN | O75496 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.32 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13616143 | 0.77 | ADRA2A (0.42) | CYP2D6ADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL12870235 | 0.77 | — | — | |
| SCHEMBL11636470 | 0.71 | ADRA2A (0.41) | CYP2D6ADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL11125378 | 0.69 | — | — | |
| SCHEMBL13616141 | 0.69 | ADRA2A (0.49) | CYP2D6ADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL11134918 | 0.69 | ADRA2A (0.49) | CYP2D6ADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL13616144 | 0.69 | ADRA2A (0.45) | CYP2D6ADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL10143149 | 0.69 | — | — | |
| SCHEMBL32681385 | 0.68 | ADRA2A (0.43) | CYP2D6ADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL11637578 | 0.68 | ADRA2A (0.47) | CYP2D6ADRA2AADRA2BADRA2CADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0420606-B1 | Use of 2-cycloalkylamino oxazolines for reducing or maintaining intraocular pressure | ALLERGAN INC (US) | 1996-03-20 | — | — | EP | disclosed |