SCHEMBL8973631

SCHEMBL8973631

COc1ccc2nn(-c3ccc(O)cc3O)nc2c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TYR P14679 2/20 0.44
TRIM24 O15164 1/20 0.44
TRIM33 Q9UPN9 1/20 0.44
MAPT P10636 2/20 0.41
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
HSD17B10 Q99714 1/20 0.41
HTT P42858 1/20 0.41
ESR1 P03372 1/20 0.40
CYP1A1 P04798 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP1B1 Q16678 1/20 0.40
PDK1 Q15118 1/20 0.40
PDK2 Q15119 1/20 0.40
PDK3 Q15120 1/20 0.40
PDK4 Q16654 1/20 0.40
RIPK2 O43353 1/20 0.40
KDR P35968 1/20 0.40
KDM4E B2RXH2 2/20 0.39
GAA P10253 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29602187 1.00 TYR (0.44) TYRTRIM24TRIM33MAPTMEN1
SCHEMBL29870382 0.86 HTT (0.56) TYRTRIM24TRIM33MAPTMEN1
SCHEMBL9180373 0.86 HTT (0.56) TYRTRIM24TRIM33MAPTMEN1
SCHEMBL10441266 0.86 MEN1 (0.48) TYRTRIM24TRIM33MAPTMEN1
SCHEMBL9638513 0.86 TRIM24 (0.42) TYRTRIM24TRIM33MAPTMEN1
SCHEMBL29492118 0.86 TRIM24 (0.42) TYRTRIM24TRIM33MAPTMEN1
SCHEMBL17201891 0.84 NPC1 (0.42) TYRMAPTMEN1KMT2AHSD17B10
SCHEMBL11594462 0.84 LMNA (0.49) TYRTRIM24TRIM33MAPTMEN1
SCHEMBL8973835 0.83 MAOB (0.46) MAPTMEN1KMT2AESR1RIPK2
SCHEMBL21630095 0.82 KDM4E (0.49) TYRTRIM24TRIM33HSD17B10HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12504568-B2 Photochromic-dichroic articles TRANSITIONS OPTICAL, LTD. (IE) 2025-12-23 US disclosed
EP-4244305-B1 PHOTOCHROMIC-DICHROIC ARTICLES TRANSITIONS OPTICAL LTD (IE) 2025-05-21 EP disclosed
US-20230400616-A1 Photochromic-Dichroic Articles TRANSITIONS OPTICAL, LTD. (IE) 2023-12-14 US disclosed
CN-116391009-A Photochromic-dichroic articles 光学转变有限公司 2023-07-04 CN disclosed
US-5585228-A Benzotriazole based UV absorbing compounds and photographic elements containing them EASTMAN KODAK COMPANY (US) 1996-12-17 US disclosed
US-5554759-A Benzotriazole based uv absorbing monomers and photographic elements containg polymers formed them EASTMAN KODAK COMPANY (US) 1996-09-10 US disclosed
EP-0717313-A1 Benzotriazole based UV absorbing compounds and photographic elements containing them EASTMAN KODAK COMPANY (US) 1996-06-19 EP disclosed
EP-0704754-A2 Benzotriazole based UV absorbing monomers and photographic elements containing polymers formed from them EASTMAN KODAK COMPANY (US) 1996-04-03 EP disclosed
US-5455152-A Maintain whiteness provided by optical brighteners EASTMAN KODAK COMPANY (US) 1995-10-03 US disclosed
US-5099027-A 2(2-hydroxyphenyl)2H-benzotriazole compounds and homopolymers or copolymers thereof PPG INDUSTRIES, INC. (US) 1992-03-24 US disclosed
US-4271307-A Bichromophoric benzotriazole-benzoxazole ultraviolet stabilizers and their use in organic compositions EASTMAN KODAK COMPANY (US) 1981-06-02 US disclosed
US-4076687-A Bichromophoric benzotriazole-benzoxazole ultraviolet stabilizers and their use in organic compositions EASTMAN KODAK COMPANY (US) 1978-02-28 US disclosed