Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | ERN1 | O75460 | 1/20 | 0.31 |
| ▸ | CTSL | P07711 | 1/20 | 0.30 |
| ▸ | CTSS | P25774 | 1/20 | 0.30 |
| ▸ | CTSK | P43235 | 1/20 | 0.30 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8974801 | 0.91 | GAA (0.36) | ELANEGAAALDH1A1NPC1RAB9A | |
| SCHEMBL8974716 | 0.87 | CA1 (0.43) | ELANEGAAALDH1A1NPC1RAB9A | |
| SCHEMBL9025783 | 0.84 | HTR1A (0.38) | GAAALDH1A1NPC1RAB9ACA1 | |
| SCHEMBL11926109 | 0.82 | CA1 (0.36) | GAAALDH1A1NPC1RAB9ACA1 | |
| SCHEMBL8974775 | 0.80 | SMN1; SMN2 (0.36) | ELANEGAAALDH1A1 | |
| SCHEMBL22914882 | 0.77 | ADRB2 (0.37) | GAAALDH1A1NPC1RAB9ACA1 | |
| SCHEMBL27806563 | 0.76 | CA1 (0.45) | GAAALDH1A1NPC1RAB9ACA1 | |
| SCHEMBL19383789 | 0.76 | CA1 (0.40) | GAAALDH1A1NPC1RAB9ACA1 | |
| SCHEMBL8974137 | 0.76 | MCL1 (0.36) | ALDH1A1TDP1L3MBTL1ERN1 | |
| SCHEMBL8974556 | 0.75 | ELANE (0.39) | ELANEGAAPTPN1CTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5527948-A | SUBSTITUTED NAPHTHYL-ALKENOIC ACIDS FOR TREATING AUTOIMMUNE DISORDERS | EISAI CORP. LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| US-5298649-A | Antiinflammatory agents, rheumatic agents and treatment of autoimmune diseases | EISAI CO., LTD. (JP) | 1994-03-29 | — | — | US | disclosed |
| EP-0376288-B1 | Naphthalene derivative | EISAI CO LTD (JP) | 1994-03-09 | — | — | EP | disclosed |
| US-5134111-A | Inhibitors of interleukin-1 as antiinflammatory agents | EISAI CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0376288-A1 | Naphthalene derivative | Eisai Co., Ltd. (JP) | 1990-07-04 | — | — | EP | disclosed |