Triaziquone

Triaziquone

SCHEMBL8974524

CNO.O=C1C=C(N2CC2)C(=O)C(N2CC2)=C1N1CC1

nearest known ligand 0.42

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.42
HTT P42858 2/20 0.42
TP53 P04637 1/20 0.42
STAT3 P40763 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
DNMT1 P26358 1/20 0.41
NSD2 O96028 4/20 0.34
APAF1 O14727 3/20 0.34
TDP2 O95551 3/20 0.34
HKDC1 Q2TB90 3/20 0.34
TTR P02766 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2D6 P10635 1/20 0.33
TSHR P16473 1/20 0.33
MAPK1 P28482 1/20 0.33
HIF1A Q16665 1/20 0.33
KMT2A Q03164 3/20 0.33
MEN1 O00255 2/20 0.33
NPC1 O15118 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Triaziquone SCHEMBL1546343 0.98 MAPT (0.41) MAPTHTTTP53STAT3SMN1; SMN2
Triaziquone SCHEMBL7117809 0.92 MAPT (0.44) MAPTHTTTP53STAT3SMN1; SMN2
Triaziquone SCHEMBL7783197 0.90 MAPT (0.46) MAPTHTTTP53STAT3SMN1; SMN2
Triaziquone SCHEMBL10440466 0.89 MAPT (0.42) MAPTHTTTP53STAT3SMN1; SMN2
Triaziquone SCHEMBL9794506 0.89 MAPT (0.42) MAPTHTTTP53STAT3SMN1; SMN2
Triaziquone SCHEMBL17874437 0.89 HTT (0.42) MAPTHTTTP53STAT3SMN1; SMN2
Triaziquone SCHEMBL2063810 0.89 MAPT (0.44) MAPTHTTTP53STAT3SMN1; SMN2
Triaziquone SCHEMBL8303 0.88 DNMT1 (0.48) MAPTHTTTP53STAT3SMN1; SMN2
Triaziquone SCHEMBL8829051 0.88 MAPT (0.42) MAPTHTTTP53STAT3SMN1; SMN2
Triaziquone SCHEMBL887253 0.88 MAPT (0.39) MAPTHTTTP53STAT3SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0704053-A1 ANALYSIS OF ANALYTES IN BIOLOGICAL FLUIDS BECKMAN INSTRUMENTS, INC. (US) 1996-04-03 EP disclosed
WO-1995028637-A1 ANALYSIS OF ANALYTES IN BIOLOGICAL FLUIDS BECKMAN INSTRUMENTS, INC. (US) 1995-10-26 WO disclosed
EP-0065905-B1 STABILIZING AGENTS FOR LIVE VIRUSES FOR THE PREPARATION OF VACCINES, AND STABILIZED VACCINES CONTAINING THESE STABILIZING AGENTS INSTITUT PASTEUR (FR) 1984-10-10 EP disclosed