Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ERN1 | O75460 | 6/20 | 0.41 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TLR2 | O60603 | 1/20 | 0.37 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.37 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8973784 | 0.85 | ERN1 (0.41) | MCL1ALDH1A1TDP1KDM4ETSHR | |
| SCHEMBL1002837 | 0.84 | MCL1 (0.68) | MCL1ALDH1A1TDP1KDM4ETSHR | |
| SCHEMBL8973873 | 0.84 | MCL1 (0.51) | MCL1ALDH1A1TDP1KDM4ETSHR | |
| SCHEMBL8973931 | 0.82 | PTPN1 (0.42) | MCL1ALDH1A1TDP1KDM4ETSHR | |
| SCHEMBL8974298 | 0.81 | MCL1 (0.38) | MCL1ALDH1A1TDP1KDM4ETSHR | |
| SCHEMBL8974396 | 0.79 | MCL1 (0.36) | MCL1ALDH1A1TDP1KDM4ETSHR | |
| SCHEMBL8974137 | 0.79 | MCL1 (0.36) | MCL1ALDH1A1TDP1KDM4ETSHR | |
| SCHEMBL3213856 | 0.75 | SRC (0.56) | ALDH1A1KDM4ETSHRERN1NPC1 | |
| SCHEMBL31346762 | 0.74 | MCL1 (0.58) | MCL1ALDH1A1TDP1KDM4ETSHR | |
| SCHEMBL1506977 | 0.74 | MCL1 (0.58) | MCL1ALDH1A1TDP1KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5527948-A | SUBSTITUTED NAPHTHYL-ALKENOIC ACIDS FOR TREATING AUTOIMMUNE DISORDERS | EISAI CORP. LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| US-5298649-A | Antiinflammatory agents, rheumatic agents and treatment of autoimmune diseases | EISAI CO., LTD. (JP) | 1994-03-29 | — | — | US | disclosed |
| EP-0376288-B1 | Naphthalene derivative | EISAI CO LTD (JP) | 1994-03-09 | — | — | EP | disclosed |
| US-5134111-A | Inhibitors of interleukin-1 as antiinflammatory agents | EISAI CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0376288-A1 | Naphthalene derivative | Eisai Co., Ltd. (JP) | 1990-07-04 | — | — | EP | disclosed |