Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.51 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.33 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8974651 | 0.84 | MCL1 (0.54) | MCL1ERN1ALDH1A1TSHRHTT | |
| SCHEMBL8974131 | 0.81 | PTGER4 (0.41) | PTPN1ALDH1A1SMN1; SMN2KDM4EGAA | |
| SCHEMBL8974134 | 0.81 | PTGER4 (0.41) | PTPN1ALDH1A1SMN1; SMN2KDM4EGAA | |
| SCHEMBL18760476 | 0.78 | PTPN1 (0.36) | ERN1PTPN1ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL8973931 | 0.75 | PTPN1 (0.42) | MCL1ERN1PTPN1ALDH1A1TSHR | |
| SCHEMBL30071915 | 0.75 | ERN1 (0.51) | MCL1ERN1ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL2043979 | 0.74 | PTPN1 (0.53) | ERN1PTPN1ALDH1A1TSHRHTT | |
| SCHEMBL20607498 | 0.74 | PTPN1 (0.33) | PTPN1ALDH1A1TSHRKDM4ETDP1 | |
| SCHEMBL9748117 | 0.74 | ERN1 (0.47) | MCL1ERN1PTPN1ALDH1A1HTT | |
| SCHEMBL20563726 | 0.74 | ERN1 (0.50) | MCL1ERN1ALDH1A1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5527948-A | SUBSTITUTED NAPHTHYL-ALKENOIC ACIDS FOR TREATING AUTOIMMUNE DISORDERS | EISAI CORP. LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| US-5298649-A | Antiinflammatory agents, rheumatic agents and treatment of autoimmune diseases | EISAI CO., LTD. (JP) | 1994-03-29 | — | — | US | disclosed |
| US-5134111-A | Inhibitors of interleukin-1 as antiinflammatory agents | EISAI CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0376288-A1 | Naphthalene derivative | Eisai Co., Ltd. (JP) | 1990-07-04 | — | — | EP | disclosed |