Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 14/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8974427 | 0.93 | PTGDR2 (0.39) | PTGS2PTGS1 | |
| SCHEMBL8974507 | 0.91 | PTGS2 (0.41) | PTGS2PTGS1 | |
| SCHEMBL8973806 | 0.87 | PTGS2 (0.43) | PTGS2PTGS1KDRMAPK14GPR119 | |
| SCHEMBL8974558 | 0.87 | PTGS2 (0.49) | PTGS2PTGS1 | |
| SCHEMBL8974416 | 0.87 | CA2 (0.41) | PTGS2PTGS1 | |
| SCHEMBL8974486 | 0.86 | PTGS2 (0.42) | PTGS2PTGS1GPR119 | |
| SCHEMBL8974718 | 0.84 | PTGS2 (0.39) | PTGS2PTGS1GPR119 | |
| SCHEMBL8974225 | 0.82 | PTGS2 (0.46) | PTGS2PTGS1KDRMAPK14GPR119 | |
| SCHEMBL8974772 | 0.82 | PTGS2 (0.46) | PTGS2PTGS1KDRMAPK14GPR119 | |
| SCHEMBL8974518 | 0.81 | PTGS2 (0.44) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5576339-A | Pyridyl substituted cyclopentadienes for the treatment of inflamation | HUANG HORNG-CHIH (US) | 1996-11-19 | — | — | US | disclosed |
| US-5418254-A | Side effect reduction | G. D. SEARLE & CO. (US) | 1995-05-23 | — | — | US | disclosed |