Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRB | P28702 | 2/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.38 |
| ▸ | MAPK6 | Q16659 | 2/20 | 0.38 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.38 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8975131 | 0.91 | LRRK2 (0.52) | RXRBRXRALRRK2PTGS2MAP2K4 | |
| SCHEMBL7777889 | 0.87 | PTGS2 (0.49) | LRRK2NR1H2PTGS2PTGS1 | |
| SCHEMBL7778114 | 0.85 | LRRK2 (0.47) | LRRK2PTGS2PTGDR2PTGS1MAPK1 | |
| SCHEMBL7780442 | 0.82 | PTGS2 (0.51) | LRRK2NR1H2PTGS2PTGS1GYS1 | |
| SCHEMBL7780652 | 0.82 | PTGS2 (0.53) | LRRK2NR1H2PTGS2PTGS1MAPT | |
| SCHEMBL7772850 | 0.81 | PTGS2 (0.51) | LRRK2NR1H2PTGS2PTGDR2PTGS1 | |
| SCHEMBL7779584 | 0.81 | PTGS2 (0.58) | LRRK2PTGS2PTGS1MEN1MAPT | |
| SCHEMBL7779772 | 0.81 | LRRK2 (0.50) | LRRK2PTGS2PTGS1 | |
| SCHEMBL7779920 | 0.80 | LRRK2 (0.53) | LRRK2NR1H2PTGS2PTGS1 | |
| SCHEMBL7780827 | 0.80 | LRRK2 (0.48) | LRRK2PTGS2MAPK1MAP2K4MAPK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5486534-A | 3,4-substituted pyrazoles for the treatment of inflammation | G. D. SEARLE & CO. (US) | 1996-01-23 | — | — | US | disclosed |