Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 10/20 | 0.52 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | RXRB | P28702 | 1/20 | 0.44 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.41 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | GPR55 | Q9Y2T6 | 3/20 | 0.39 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | GYS1 | P13807 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8974767 | 0.91 | RXRB (0.44) | LRRK2RXRARXRBMAP2K4PTGS2 | |
| SCHEMBL7780622 | 0.87 | LRRK2 (0.57) | LRRK2MAP2K7MAP2K4PTGS2GYS1 | |
| SCHEMBL7779735 | 0.85 | LRRK2 (0.57) | LRRK2MAP2K7MAP2K4PTGS2MAPT | |
| SCHEMBL7777855 | 0.83 | LRRK2 (0.55) | LRRK2MAP2K7MAP2K4PTGS2GYS1 | |
| SCHEMBL7780114 | 0.82 | PTGS2 (0.54) | LRRK2PTGS2MAPTGPR55CNR1 | |
| SCHEMBL7777620 | 0.81 | LRRK2 (0.60) | LRRK2MAP2K7MAP2K4PTGS2CA12 | |
| SCHEMBL7777532 | 0.81 | LRRK2 (0.53) | LRRK2MAP2K7MAP2K4PTGS2MAPT | |
| SCHEMBL7779616 | 0.81 | LRRK2 (0.64) | LRRK2MAP2K7MAP2K4PTGS2CA1 | |
| SCHEMBL7773326 | 0.80 | LRRK2 (0.68) | LRRK2MAP2K7MAP2K4PTGS2MAPT | |
| SCHEMBL7780655 | 0.79 | CA12 (0.57) | LRRK2MAP2K4PTGS2MAPTGPR55 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5486534-A | 3,4-substituted pyrazoles for the treatment of inflammation | G. D. SEARLE & CO. (US) | 1996-01-23 | — | — | US | disclosed |