Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | CES1 | P23141 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7203020 | 0.84 | TDP1 (0.53) | L3MBTL1TDP1MAPTLMNANR4A2 | |
| SCHEMBL276676 | 0.81 | NR4A2 (0.65) | L3MBTL1TDP1MAPTLMNANR4A2 | |
| SCHEMBL719034 | 0.79 | NR4A2 (0.85) | L3MBTL1TDP1MAPTLMNANR4A2 | |
| SCHEMBL30121738 | 0.79 | NR4A2 (0.85) | L3MBTL1TDP1MAPTLMNANR4A2 | |
| SCHEMBL28180778 | 0.79 | L3MBTL1 (0.57) | L3MBTL1TDP1MAPTLMNANR4A2 | |
| SCHEMBL317112 | 0.79 | MAPT (0.57) | L3MBTL1TDP1MAPTLMNANR4A2 | |
| SCHEMBL8608674 | 0.79 | TDP1 (0.57) | L3MBTL1TDP1MAPTLMNANR4A2 | |
| SCHEMBL7324959 | 0.79 | TDP1 (0.52) | L3MBTL1TDP1MAPTLMNANR4A2 | |
| SCHEMBL18755271 | 0.78 | NR4A2 (0.68) | L3MBTL1TDP1MAPTLMNANR4A2 | |
| SCHEMBL9211933 | 0.78 | TDP1 (0.56) | L3MBTL1TDP1MAPTLMNANR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0543919-B1 | USE OF HETEROCYCLIC AMINO-ALCOHOL COMPOUNDS IN THE MANUFACTURE OF A MEDICAMENT FOR TREATMENT OF CNS DISEASES | SEARLE & CO (US) | 1996-04-10 | — | — | EP | claimed |
| EP-0543919-A1 | USE OF HETEROCYCLIC AMINO-ALCOHOL COMPOUNDS FOR TREATMENT OF CNS DISEASES. | SEARLE & CO (US) | 1993-06-02 | — | — | EP | claimed |
| WO-1992003131-A1 | USE OF HETEROCYCLIC AMINO-ALCOHOL COMPOUNDS FOR TREATMENT OF CNS DISEASES | G.D. SEARLE & CO. (US) | 1992-03-05 | — | — | WO | claimed |
| US-4173636-A | Decahydroquinolines, pharmaceutical compositions and methods of use | LABAZ (FR) | 1979-11-06 | — | — | US | claimed |
| EP-0002283-A1 | Substituted 1,3-dihydrospiro (benzo(c)thiophenes), process for their preparation and these compounds for use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-06-13 | — | — | EP | claimed |
| EP-0543919-B1 | USE OF HETEROCYCLIC AMINO-ALCOHOL COMPOUNDS IN THE MANUFACTURE OF A MEDICAMENT FOR TREATMENT OF CNS DISEASES | SEARLE & CO (US) | 1996-04-10 | — | — | EP | disclosed |
| US-5462965-A | Use of heterocyclic amino-alcohol compounds for treatment of CNS diseases | GD SEARLE & CO. (US) | 1995-10-31 | — | — | US | disclosed |
| EP-0543919-A1 | USE OF HETEROCYCLIC AMINO-ALCOHOL COMPOUNDS FOR TREATMENT OF CNS DISEASES. | SEARLE & CO (US) | 1993-06-02 | — | — | EP | disclosed |
| WO-1992003131-A1 | USE OF HETEROCYCLIC AMINO-ALCOHOL COMPOUNDS FOR TREATMENT OF CNS DISEASES | G.D. SEARLE & CO. (US) | 1992-03-05 | — | — | WO | disclosed |
| US-4301292-A | 1-[2-(4,5-Dihydro-4,4-dialkyl-2-oxazolyl)phenyl]-4-(dialkylamino)cyclohexanol | HOECHST-ROUSSEL PHARMACEUTICALS, INCORPORATED (US) | 1981-11-17 | — | — | US | disclosed |
| US-4292243-A | 3\"-Phenyldispiro[1,3-dioxolane-2,4'-cyclohexane-1',1\"-(3\"H)-isobenzofuran] | HOECHST ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1981-09-29 | — | — | US | disclosed |
| US-4292245-A | 3'-Phenylspiro[cyclohexane-1,1'(3'H)-isobenzofuran]-4-one | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1981-09-29 | — | — | US | disclosed |
| US-4290958-A | Spiro[cyclohexane-1,1'(3'H)-isobenzofuran]s | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1981-09-22 | — | — | US | disclosed |
| US-4288623-A | 1-Aryl-4-amino-cyclohexan-1-ols | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1981-09-08 | — | — | US | disclosed |
| EP-0029286-A1 | Pyrrolo(3,4-c)quinoline derivatives, processes therefor, and pharmaceutical compositions | ICI AMERICAS INC. (US) | 1981-05-27 | — | — | EP | disclosed |
| EP-0027522-A1 | Spiro(cyclohexane-1,1'(3'H)-isobenzofuran)s, processes and intermediates for their preparation and pharmaceutical compositions containing them | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1981-04-29 | — | — | EP | disclosed |
| US-4263317-A | Spiro[cyclohexane-1,1'(3'H)-isobenzofuran]s | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1981-04-21 | — | — | US | disclosed |
| US-4064128-A | SEDATIVES | KALI-CHEMIE AKTIENGESELLSCHAFT (DT) | 1977-12-20 | — | — | US | disclosed |
| US-4022786-A | PHARMACEUTICALS, CNS STIMULANT | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DT) | 1977-05-10 | — | — | US | disclosed |
| US-4016280-A | 4,4-Diarylpiperidine compositions and use | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DT) | 1977-04-05 | — | — | US | disclosed |