Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 15/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8974164 | 0.88 | PTGS2 (0.61) | PTGS2PTGS1LMNA | |
| SCHEMBL8974723 | 0.85 | PTGS2 (0.71) | PTGS2PTGS1 | |
| SCHEMBL8974230 | 0.85 | PTGS2 (0.65) | PTGS2PTGS1 | |
| SCHEMBL8974453 | 0.84 | PTGS2 (0.55) | PTGS2PTGS1LMNA | |
| SCHEMBL14499498 | 0.84 | PTGS2 (0.71) | PTGS2PTGS1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL9116789 | 0.83 | PTGS2 (0.76) | PTGS2PTGS1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL8974106 | 0.82 | PTGS2 (0.48) | PTGS2PTGS1SMN1; SMN2LMNAHPGD | |
| SCHEMBL8973736 | 0.80 | PTGS2 (0.58) | PTGS2PTGS1 | |
| SCHEMBL8974318 | 0.80 | PTGS2 (0.62) | PTGS2PTGS1 | |
| SCHEMBL8974141 | 0.79 | PTGS2 (0.62) | PTGS2PTGS1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995030656-A1 | SUBSTITUTED CYCLOPENTADIENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-11-16 | — | — | WO | claimed |
| US-5576339-A | Pyridyl substituted cyclopentadienes for the treatment of inflamation | HUANG HORNG-CHIH (US) | 1996-11-19 | — | — | US | disclosed |
| WO-1995030656-A1 | SUBSTITUTED CYCLOPENTADIENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-11-16 | — | — | WO | disclosed |
| US-5418254-A | Side effect reduction | G. D. SEARLE & CO. (US) | 1995-05-23 | — | — | US | disclosed |