Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 16/20 | 0.76 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9118113 | 0.90 | PTGS2 (0.79) | PTGS2PTGS1SMN1; SMN2 | |
| SCHEMBL9119158 | 0.89 | PTGS2 (0.60) | PTGS2PTGS1 | |
| SCHEMBL9118082 | 0.86 | PTGS2 (0.58) | PTGS2PTGS1SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL9116776 | 0.86 | PTGS2 (0.74) | PTGS2PTGS1 | |
| SCHEMBL9117120 | 0.86 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL9117634 | 0.85 | PTGS2 (0.57) | PTGS2PTGS1SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL9118399 | 0.85 | PTGS2 (0.57) | PTGS2PTGS1SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL9117749 | 0.83 | PTGS2 (0.70) | PTGS2PTGS1 | |
| SCHEMBL9117982 | 0.83 | PTGS2 (0.69) | PTGS2PTGS1 | |
| SCHEMBL8974923 | 0.83 | PTGS2 (0.60) | PTGS2PTGS1SMN1; SMN2LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995030652-A1 | SUBSTITUTED SPIRODIENES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-11-16 | — | — | WO | claimed |
| WO-1995030652-A1 | SUBSTITUTED SPIRODIENES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-11-16 | — | — | WO | disclosed |