Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 5/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 3/20 | 0.70 |
| ▸ | EGFR | P00533 | 1/20 | 0.70 |
| ▸ | APP | P05067 | 1/20 | 0.70 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.69 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.69 |
| ▸ | CNR1 | P21554 | 1/20 | 0.69 |
| ▸ | CNR2 | P34972 | 1/20 | 0.69 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | PPARG | P37231 | 1/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.58 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.58 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.58 |
| ▸ | CCNC | P24863 | 1/20 | 0.57 |
| ▸ | CDKN1A | P38936 | 1/20 | 0.57 |
| ▸ | CDK8 | P49336 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9921509 | 0.89 | PIK3CD (0.85) | HTTMAPK1LMNAEGFRAPP | |
| SCHEMBL8548141 | 0.87 | MAPK1 (0.62) | HTTMAPK1LMNAEGFRAPP | |
| SCHEMBL11846406 | 0.85 | KDM4E (0.63) | HTTMAPK1LMNAPIK3CDPIK3R1 | |
| SCHEMBL8540683 | 0.85 | HTT (0.65) | HTTMAPK1LMNAEGFRAPP | |
| SCHEMBL3979500 | 0.83 | KDM4E (0.77) | HTTMAPK1LMNAPIK3CDPIK3R1 | |
| SCHEMBL8497590 | 0.83 | APP (1.00) | HTTMAPK1LMNAEGFRAPP | |
| SCHEMBL8541525 | 0.82 | HTT (0.81) | HTTMAPK1LMNAEGFRAPP | |
| SCHEMBL17557570 | 0.82 | CNR1 (1.00) | HTTMAPK1LMNAEGFRAPP | |
| SCHEMBL9921357 | 0.82 | PIK3CD (1.00) | HTTMAPK1LMNAEGFRAPP | |
| SCHEMBL11855329 | 0.81 | HDAC1 (0.60) | HTTMAPK1LMNAPIK3CDPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705253-A1 | ARALKYLAMINOQUINAZOLINES | BAYER AG (DE) | 1996-04-10 | — | — | EP | claimed |
| WO-1995000496-A1 | ARALKYLAMINOQUINAZOLINES | BAYER AKTIENGESELLSCHAFT (DE) | 1995-01-05 | — | — | WO | claimed |
| EP-0705253-A1 | ARALKYLAMINOQUINAZOLINES | BAYER AG (DE) | 1996-04-10 | — | — | EP | disclosed |
| WO-1995000496-A1 | ARALKYLAMINOQUINAZOLINES | BAYER AKTIENGESELLSCHAFT (DE) | 1995-01-05 | — | — | WO | disclosed |