SCHEMBL8975472

SCHEMBL8975472

O=C(NCCCN1CCCCCC1)C(c1ccsc1)C1CCCCC1

nearest known ligand 0.72

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.72
CYP1A2 P05177 1/20 0.72
CYP3A4 P08684 1/20 0.72
CYP2D6 P10635 1/20 0.72
TSHR P16473 1/20 0.72
TDP1 Q9NUW8 1/20 0.72
ADRA1D P25100 2/20 0.56
ADRA1A P35348 2/20 0.56
ADRA1B P35368 2/20 0.56
RAD52 P43351 1/20 0.53
C3AR1 Q16581 1/20 0.46
CCR2 P41597 2/20 0.46
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
SLC6A2 P23975 1/20 0.43
SLC6A3 Q01959 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL194768 0.84 TP53 (1.00) TP53CYP1A2CYP3A4CYP2D6TSHR
SCHEMBL4876834 0.82 TP53 (0.98) TP53CYP1A2CYP3A4CYP2D6TSHR
Cetiedil SCHEMBL458084 0.78 CYP3A4 (0.44) TP53CYP1A2CYP3A4CYP2D6TSHR
Cetiedil SCHEMBL14169136 0.78 CYP3A4 (0.44) TP53CYP1A2CYP3A4CYP2D6TSHR
SCHEMBL4877646 0.75 TP53 (0.84) TP53CYP1A2CYP3A4CYP2D6TSHR
SCHEMBL8975688 0.74 TP53 (0.66) TP53CYP1A2CYP3A4CYP2D6TSHR
SCHEMBL12181203 0.73 MAPT (0.55) CYP1A2CYP2D6TSHRKMT2AL3MBTL1
SCHEMBL11147057 0.72 C3AR1 (0.44) CYP1A2CYP3A4CYP2D6TSHRADRA1A
Cetiedil SCHEMBL121380 0.72 CYP3A4 (0.40) TP53CYP1A2CYP3A4CYP2D6TSHR
SCHEMBL7601155 0.71 TP53 (0.70) TP53CYP1A2CYP3A4CYP2D6TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0475844-B1 Use of N-(1.hexahydroazepinylalkyl) acetamides for the manufacture of medicaments for the treatment of disorders of the cholineogic transmission UNIV CAEN (FR) 1996-04-17 EP claimed
US-5200405-A USE OF N-(1-HEXAHYDROAZEPINYLALKYL) ACETAMIDES FOR THE TREATMENT OF CHOLINERGIC TRANSMISSION DISORDERS ADIR ET COMPAGNIE (FR) 1993-04-06 US claimed
JP-4257521-A None JP disclosed
US-5200405-A USE OF N-(1-HEXAHYDROAZEPINYLALKYL) ACETAMIDES FOR THE TREATMENT OF CHOLINERGIC TRANSMISSION DISORDERS ADIR ET COMPAGNIE (FR) 1993-04-06 US disclosed
JP-H04257521-A N-(1-HEXAHYDROAZEPINYLALKYL)ACETAMIDE COMPOUND-CONTAINING PHARMACEUTICAL COMPOSITION FOR CHOLINERGIC TRANSMISSION DISORDER TREATMENT ADIR 1992-09-11 JP disclosed