SCHEMBL8975728

SCHEMBL8975728

O=C(O)c1cccc2nc(S)sc12

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.46
MAPT P10636 2/20 0.41
HDAC8 Q9BY41 1/20 0.41
NR4A1 P22736 1/20 0.39
NR4A2 P43354 1/20 0.39
NR4A3 Q92570 1/20 0.39
ALOX15 P16050 1/20 0.39
DHODH Q02127 2/20 0.39
KDM4E B2RXH2 3/20 0.38
HSD17B10 Q99714 2/20 0.38
CASP1 P29466 1/20 0.38
CASP7 P55210 1/20 0.38
MEN1 O00255 3/20 0.38
KMT2A Q03164 3/20 0.38
NPC1 O15118 2/20 0.38
RAB9A P51151 2/20 0.38
SMN1; SMN2 Q16637 3/20 0.37
LMNA P02545 2/20 0.37
RXFP1 Q9HBX9 2/20 0.36
GLA P06280 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17859467 0.81 ALDH1A1 (0.47) ALDH1A1MAPTNR4A1NR4A2NR4A3
SCHEMBL5118299 0.81 ALDH1A1 (0.47) ALDH1A1MAPTNR4A1NR4A2NR4A3
SCHEMBL20969720 0.79 ALDH1A1 (0.46) ALDH1A1MAPTNR4A1NR4A2NR4A3
SCHEMBL687318 0.79 ALDH1A1 (0.46) ALDH1A1MAPTNR4A1NR4A2NR4A3
SCHEMBL5116616 0.77 SMN1; SMN2 (0.51) ALDH1A1DHODHKDM4ENPC1RAB9A
SCHEMBL7556888 0.77 ALDH1A1 (0.45) ALDH1A1MAPTKDM4EMEN1KMT2A
SCHEMBL9305472 0.76 APP (0.46) ALDH1A1MAPTHDAC8ALOX15KDM4E
SCHEMBL20859029 0.76 TLR8 (0.44) ALDH1A1ALOX15DHODHKDM4EMEN1
Salicylic Acid SCHEMBL9153103 0.73 SMN1; SMN2 (0.53) ALDH1A1MAPTALOX15KDM4EHSD17B10
SCHEMBL1935472 0.72 ALDH1A1 (0.46) ALDH1A1MAPTHDAC8NR4A1NR4A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5565445-A ANTIBIOTICS, USEFUL AGAINST METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS OR STAPHYLOCOCCUS EPIDERMIDIS AND METHICILLIN RESITANT COAGULASE NEGATIVE STAPHYLOCOCCI MERCK & CO., INC. (US) 1996-10-15 US disclosed
US-5541176-A ANTIBIOTICS, USEFUL AGAINST METHICILLIN RESISTANT STAPHYLOCOCCUS MERCK & CO., INC. (US) 1996-07-30 US disclosed
US-5538964-A ANTIBIOTICS FOR BACTERICIDES MERCK & CO., INC. (US) 1996-07-23 US disclosed
US-5498777-A 3-thioheteroaryl cephalosporin compounds, compositions and methods of use MERCK & CO., INC. (US) 1996-03-12 US disclosed
WO-1996002548-A1 3-THIOHETEROARYL CEPHALOSPORIN COMPOUNDS, COMPOSITIONS AND METHODS OF USE MERCK & CO., INC. (US) 1996-02-01 WO disclosed