Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 2/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | PI4KA | P42356 | 1/20 | 0.30 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8975962 | 0.74 | HSD17B10 (0.65) | HSD17B10DYRK1AAPP | |
| SCHEMBL8975913 | 0.70 | APP (0.52) | HSD17B10APPPIK3CAPI4KAPI4KB | |
| SCHEMBL4281170 | 0.69 | HSD17B10 (0.35) | HSD17B10 | |
| SCHEMBL3549488 | 0.68 | HSD17B10 (0.34) | HSD17B10 | |
| SCHEMBL24660285 | 0.66 | LMNA (0.39) | HSD17B10S1PR1S1PR3 | |
| SCHEMBL8975713 | 0.64 | CCR1 (0.41) | PIK3CAPI4KAPI4KB | |
| SCHEMBL6405742 | 0.64 | KRAS (0.39) | HSD17B10DYRK1AAPP | |
| SCHEMBL21104584 | 0.62 | TRPV1 (0.41) | S1PR1 | |
| SCHEMBL21104585 | 0.62 | TRPV1 (0.42) | HSD17B10 | |
| SCHEMBL1754158 | 0.62 | HDAC6 (0.34) | PIK3CAPI4KAPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5565445-A | ANTIBIOTICS, USEFUL AGAINST METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS OR STAPHYLOCOCCUS EPIDERMIDIS AND METHICILLIN RESITANT COAGULASE NEGATIVE STAPHYLOCOCCI | MERCK & CO., INC. (US) | 1996-10-15 | — | — | US | disclosed |
| US-5541176-A | ANTIBIOTICS, USEFUL AGAINST METHICILLIN RESISTANT STAPHYLOCOCCUS | MERCK & CO., INC. (US) | 1996-07-30 | — | — | US | disclosed |
| US-5538964-A | ANTIBIOTICS FOR BACTERICIDES | MERCK & CO., INC. (US) | 1996-07-23 | — | — | US | disclosed |
| US-5498777-A | 3-thioheteroaryl cephalosporin compounds, compositions and methods of use | MERCK & CO., INC. (US) | 1996-03-12 | — | — | US | disclosed |
| US-5496816-A | Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment | MERCK & CO., INC. (US) | 1996-03-05 | — | — | US | disclosed |
| WO-1996002548-A1 | 3-THIOHETEROARYL CEPHALOSPORIN COMPOUNDS, COMPOSITIONS AND METHODS OF USE | MERCK & CO., INC. (US) | 1996-02-01 | — | — | WO | disclosed |