Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | DRD4 | P21917 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8976331 | 1.00 | SMN1; SMN2 (0.62) | SMN1; SMN2USP2ALOX15TSHRTDP1 | |
| SCHEMBL8976340 | 0.91 | SMN1; SMN2 (0.68) | SMN1; SMN2USP2ALOX15TSHRTDP1 | |
| SCHEMBL8976337 | 0.91 | SMN1; SMN2 (0.68) | SMN1; SMN2USP2ALOX15TSHRTDP1 | |
| SCHEMBL8976303 | 0.89 | SMN1; SMN2 (0.62) | SMN1; SMN2USP2ALOX15TSHRTDP1 | |
| SCHEMBL8976310 | 0.89 | SMN1; SMN2 (0.62) | SMN1; SMN2USP2ALOX15TSHRTDP1 | |
| SCHEMBL8976616 | 0.85 | SIGMAR1 (0.65) | SMN1; SMN2USP2ALOX15TSHRTDP1 | |
| SCHEMBL8976614 | 0.85 | SIGMAR1 (0.65) | SMN1; SMN2USP2ALOX15TSHRTDP1 | |
| SCHEMBL13539640 | 0.79 | TSHR (0.72) | SMN1; SMN2USP2ALOX15TSHRTDP1 | |
| SCHEMBL8976376 | 0.79 | MEN1 (0.67) | SMN1; SMN2ALOX15ALDH1A1MEN1KMT2A | |
| SCHEMBL8976380 | 0.79 | MEN1 (0.67) | SMN1; SMN2ALOX15ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1053441-C | Compound with 1-(aryl Chain olefine)-4-(aryl methyl) piperazine structure, preparation process thereof and medicine thereof | ADIR ET CO (FR) | 2000-06-14 | — | — | CN | disclosed |
| EP-0707004-A1 | 1-Arylalcenyl 4-arylmethylpiperazinderivatives, process for their preparation and pharmaceutical composition containing them | ADIR ET COMPAGNIE (FR) | 1996-04-17 | — | — | EP | disclosed |