Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.69 |
| ▸ | GMPS | P49915 | 2/20 | 0.66 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.59 |
| ▸ | FYN | P06241 | 1/20 | 0.56 |
| ▸ | SRC | P12931 | 1/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.53 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8976584 | 0.86 | EGFR (0.67) | EGFRERBB2FYNSRCERBB4 | |
| SCHEMBL4858749 | 0.85 | NPC1 (0.70) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL4586985 | 0.84 | EGFR (0.78) | EGFRGMPSERBB2FYNSRC | |
| SCHEMBL4354580 | 0.82 | EGFR (0.78) | EGFRGMPSERBB2 | |
| SCHEMBL4585990 | 0.82 | EGFR (1.00) | EGFRGMPSERBB2HDAC3HDAC4 | |
| SCHEMBL4585935 | 0.82 | EGFR (1.00) | EGFRGMPSERBB2FYNSRC | |
| SCHEMBL7125375 | 0.81 | EGFR (0.70) | EGFRERBB2FYNSRCPIK3CD | |
| Hydrochloric Acid SCHEMBL8104687 | 0.81 | EGFR (0.70) | EGFRGMPSERBB2HDAC3HDAC4 | |
| SCHEMBL22971857 | 0.79 | GMPS (1.00) | EGFRGMPSERBB2 | |
| SCHEMBL31318107 | 0.79 | GMPS (1.00) | EGFRGMPSERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5580870-A | ANTICARCINOGENIC AGENTS | ZENECA LIMITED (GB) | 1996-12-03 | — | — | US | disclosed |
| EP-0602851-B1 | Quinazoline derivatives | ZENECA LTD (GB) | 1996-10-09 | — | — | EP | disclosed |
| CN-1094043-A | Quinazoline derivant | ZENECA LTD (GB) | 1994-10-26 | — | — | CN | disclosed |
| EP-0602851-A1 | Quinazoline derivatives | ZENECA LIMITED (GB) | 1994-06-22 | — | — | EP | disclosed |