Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.67 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.61 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.60 |
| ▸ | LCK | P06239 | 1/20 | 0.60 |
| ▸ | FYN | P06241 | 2/20 | 0.59 |
| ▸ | SRC | P12931 | 2/20 | 0.59 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | RAF1 | P04049 | 1/20 | 0.53 |
| ▸ | BRAF | P15056 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7125375 | 0.86 | EGFR (0.70) | EGFRERBB2FYNSRCERBB4 | |
| SCHEMBL8976404 | 0.86 | EGFR (0.69) | EGFRERBB2FYNSRCERBB4 | |
| SCHEMBL1538297 | 0.84 | NPC1 (0.77) | MEN1NPC1POLBMAPTKMT2A | |
| SCHEMBL29728201 | 0.84 | NPC1 (0.77) | MEN1NPC1POLBMAPTKMT2A | |
| SCHEMBL27758510 | 0.83 | EGFR (0.76) | EGFRABCG2ERBB2LCKFYN | |
| SCHEMBL7125216 | 0.81 | EGFR (0.72) | EGFRERBB2FYNSRCERBB4 | |
| SCHEMBL2100347 | 0.81 | EGFR (0.77) | EGFRABCG2ERBB2 | |
| SCHEMBL8976408 | 0.81 | EGFR (1.00) | EGFRERBB2ERBB4MAPT | |
| SCHEMBL9974895 | 0.81 | EGFR (0.76) | EGFRABCG2ERBB2FYNSRC | |
| SCHEMBL8871003 | 0.81 | EGFR (0.76) | EGFRABCG2ERBB2MEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5580870-A | ANTICARCINOGENIC AGENTS | ZENECA LIMITED (GB) | 1996-12-03 | — | — | US | disclosed |
| EP-0602851-B1 | Quinazoline derivatives | ZENECA LTD (GB) | 1996-10-09 | — | — | EP | disclosed |
| EP-0602851-A1 | Quinazoline derivatives | ZENECA LIMITED (GB) | 1994-06-22 | — | — | EP | disclosed |