Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.65 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.65 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.65 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.65 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.65 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.65 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8977839 | 1.00 | HDAC8 (0.65) | HDAC8HDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL14454660 | 0.98 | HDAC1 (0.61) | HDAC8HDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL13024169 | 0.91 | HDAC3 (0.56) | HDAC8HDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL3451176 | 0.83 | HDAC8 (0.60) | HDAC8HDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL10253845 | 0.83 | ALDH1A1 (0.44) | HDAC8HDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL195634 | 0.83 | ALDH1A1 (0.44) | HDAC8HDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL3917890 | 0.83 | ALDH1A1 (0.44) | HDAC8HDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL9520599 | 0.81 | HDAC2 (0.52) | HDAC8HDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL9163443 | 0.81 | ALDH1A1 (0.52) | HDAC8HDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL14984414 | 0.81 | ALDH1A1 (0.52) | HDAC8HDAC1HDAC6HDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0598747-B1 | N-ETHYL HYDROXAMIC ACID CHELANTS | MET TECH SYSTEMS LTD (CA) | 1996-04-24 | — | — | EP | claimed |
| US-5487842-A | LOW VISCOSITY, RAPID PHASE SEPARATION, HYDROLYTIC STABILITY | MET-TECH SYSTEMS LIMITED (CA) | 1996-01-30 | — | — | US | claimed |
| US-5328626-A | Extraction of metals from aqueous solutions | MET-TECH SYSTEMS, LTD. (CA) | 1994-07-12 | — | — | US | claimed |
| EP-0598747-A1 | N-ETHYL HYDROXAMIC ACID CHELANTS. | MONSANTO CO (US) | 1994-06-01 | — | — | EP | claimed |
| WO-1993002047-A1 | N-ETHYL HYDROXAMIC ACID CHELANTS | MONSANTO COMPANY (US) | 1993-02-04 | — | — | WO | claimed |
| US-5174917-A | Compositions containing n-ethyl hydroxamic acid chelants | MONSANTO COMPANY (US) | 1992-12-29 | — | — | US | claimed |
| US-20200165257-A1 | INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE AND HISTONE DEACETYLASE FOR TREATMENT OF CANCER | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2020-05-28 | — | — | US | disclosed |
| US-20070155730-A1 | Benzodiazepine And Benzopiperazine Analog Inhibitors Of Histone Deacetylase | METHYLGENE, INC. (CA) | 2007-07-05 | — | — | US | disclosed |
| EP-0283740-B1 | Oxidative dissolution of gallium arsenide and separation of gallium from arsenic | MONSANTO CO (US) | 1993-11-24 | — | — | EP | disclosed |
| US-5174917-A | Compositions containing n-ethyl hydroxamic acid chelants | MONSANTO COMPANY (US) | 1992-12-29 | — | — | US | disclosed |
| US-5030427-A | Washing solutions of n-organohydaoxamic acid complexes | MONSANTO COMPANY (US) | 1991-07-09 | — | — | US | disclosed |
| US-4943646-A | WITH N-ORGANOHYDROXAMIC ACID | MONSANTO COMPANY (US) | 1990-07-24 | — | — | US | disclosed |
| US-4939299-A | Succinyl dihydroxamic acids | MONSANTO COMPANY (US) | 1990-07-03 | — | — | US | disclosed |
| EP-0344143-A2 | Gallium purification | MONSANTO COMPANY (US) | 1989-11-29 | — | — | EP | disclosed |
| EP-0283740-A2 | Oxidative dissolution of gallium arsenide and separation of gallium from arsenic | MONSANTO COMPANY (US) | 1988-09-28 | — | — | EP | disclosed |
| US-4759917-A | Contacting with oxidizing agent and hydroxamic acid to convert gallium to gallium-hydroxamic acid complex, and oxidize arsanic | MONSANTO COMPANY (US) | 1988-07-26 | — | — | US | disclosed |
| EP-0271468-A2 | Gallium complexes and solvent extraction of gallium | Monsanto Company (US) | 1988-06-15 | — | — | EP | disclosed |
| US-4741887-A | Gallium complexes and solvent extraction of gallium | MONSANTO COMPANY (US) | 1988-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200165257-A1 | INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE AND HISTONE DEACETYLASE FOR TREATMENT OF CANCER | HDAC1, HDAC3, HDAC4 | HDAC8 6/4885HDAC1 1/4885HDAC6 10/4885 |
| US-20070155730-A1 | Benzodiazepine And Benzopiperazine Analog Inhibitors Of Histone Deacetylase | HDAC5, HDAC4, HDAC3 | HDAC8 9/4885HDAC1 5/4885HDAC6 24/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.