Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 8/20 | 0.64 |
| ▸ | EDNRA | P25101 | 8/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8977941 | 0.89 | EDNRB (0.65) | EDNRBEDNRAKMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL7857521 | 0.78 | EDNRA (1.00) | EDNRBEDNRA | |
| SCHEMBL7716786 | 0.71 | EDNRB (1.00) | EDNRBEDNRA | |
| SCHEMBL7951151 | 0.71 | EDNRA (0.52) | EDNRA | |
| SCHEMBL31514325 | 0.70 | EDNRA (0.59) | EDNRBEDNRAKMT2ASMN1; SMN2MAPT | |
| SCHEMBL22427901 | 0.66 | KAT6A (0.39) | EDNRBEDNRAKMT2AMAPTMEN1 | |
| SCHEMBL2622530 | 0.64 | ALDH1A1 (0.47) | EDNRBEDNRAKMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL29652501 | 0.64 | EDNRB (0.56) | EDNRBEDNRAKMT2AMAPTMEN1 | |
| SCHEMBL21609128 | 0.64 | EDNRB (0.56) | EDNRBEDNRAKMT2AMAPTMEN1 | |
| SCHEMBL20073678 | 0.62 | EDNRB (0.47) | EDNRBEDNRAKMT2ARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5514691-A | N-(4-halo-isoxazolyl)-sulfonamides and derivatives thereof that modulate the activity of endothelin | IMMUNOPHARMACEUTICS, INC. (US) | 1996-05-07 | — | — | US | disclosed |