Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 13/20 | 0.65 |
| ▸ | EDNRA | P25101 | 13/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8977899 | 0.89 | EDNRB (0.64) | EDNRBEDNRAKMT2ASMN1; SMN2NPC1 | |
| SCHEMBL7716786 | 0.79 | EDNRB (1.00) | EDNRBEDNRA | |
| SCHEMBL7954143 | 0.74 | HTT (0.47) | EDNRBEDNRAALDH1A1TSHR | |
| SCHEMBL7371066 | 0.73 | EDNRA (0.64) | EDNRBEDNRA | |
| SCHEMBL7964834 | 0.72 | EDNRA (0.69) | EDNRBEDNRA | |
| SCHEMBL7857521 | 0.72 | EDNRA (1.00) | EDNRBEDNRA | |
| SCHEMBL8676438 | 0.72 | EDNRB (0.61) | EDNRBEDNRAKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL7857292 | 0.70 | EDNRB (1.00) | EDNRBEDNRA | |
| SCHEMBL7860475 | 0.70 | EDNRB (0.82) | EDNRBEDNRA | |
| SCHEMBL7717213 | 0.70 | EDNRA (0.67) | EDNRBEDNRAKMT2AMEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5514691-A | N-(4-halo-isoxazolyl)-sulfonamides and derivatives thereof that modulate the activity of endothelin | IMMUNOPHARMACEUTICS, INC. (US) | 1996-05-07 | — | — | US | disclosed |