Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 14/20 | 0.44 |
| ▸ | PDE4A | P27815 | 13/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.44 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7032971 | 0.99 | PDE4B (0.43) | PDE4BPDE4APDE4CPDE4DSSTR5 | |
| SCHEMBL7752296 | 0.85 | PDE4B (0.42) | PDE4BPDE4APDE4CPDE4DSSTR5 | |
| SCHEMBL1918433 | 0.79 | PDE4A (0.53) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL30074724 | 0.79 | PDE4A (0.53) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL2466397 | 0.78 | PDE4A (0.50) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7676524 | 0.77 | PDE4B (0.45) | PDE4BPDE4APDE4CPDE4DSSTR5 | |
| Hydrochloric Acid SCHEMBL4014079 | 0.77 | PDE4A (0.49) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL2466399 | 0.75 | PDE4A (0.51) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6155940 | 0.75 | PDE4A (0.53) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6155742 | 0.75 | PDE4A (0.53) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705265-A1 | NOVEL CHEMICAL COMPOUNDS HAVING PDE-IV INHIBITION ACTIVITY | Euroceltique S.A. (LU) | 1996-04-10 | — | — | EP | disclosed |