Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.48 |
| ▸ | CCR1 | P32246 | 2/20 | 0.48 |
| ▸ | CCR5 | P51681 | 2/20 | 0.48 |
| ▸ | CCR8 | P51685 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | METAP1 | P53582 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8978451 | 0.97 | LMNA (0.46) | LMNAKDM4EP4HTMCCR1CCR5 | |
| SCHEMBL8978433 | 0.97 | KDM4E (0.50) | LMNAKDM4EP4HTMCCR1CCR5 | |
| SCHEMBL18660488 | 0.97 | — | — | |
| SCHEMBL29419423 | 0.97 | — | — | |
| SCHEMBL2355 | 0.97 | — | — | |
| Benzene SCHEMBL28342353 | 0.94 | LMNA (0.48) | LMNAKDM4EP4HTMCCR1CCR5 | |
| Hydrochloric Acid SCHEMBL1868855 | 0.94 | — | — | |
| SCHEMBL1146004 | 0.94 | — | — | |
| SCHEMBL7209441 | 0.94 | — | — | |
| SCHEMBL8504418 | 0.94 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0532861-B1 | Method for producing a carbonic acid ester | MITSUBISHI CHEM CORP (JP) | 1996-05-01 | — | — | EP | disclosed |
| US-5227510-A | 2-Hydroxypyridine Complexes | MITSUBISHI KASEI CORPORATION (JP) | 1993-07-13 | — | — | US | disclosed |
| EP-0532861-A1 | Method for producing a carbonic acid ester | Mitsubishi Chemical Corporation (JP) | 1993-03-24 | — | — | EP | disclosed |