Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.60 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.60 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | NT5E | P21589 | 1/20 | 0.53 |
| ▸ | CA4 | P22748 | 1/20 | 0.53 |
| ▸ | CA6 | P23280 | 1/20 | 0.53 |
| ▸ | CA5A | P35218 | 1/20 | 0.53 |
| ▸ | CA7 | P43166 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.41 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.41 |
| ▸ | BLM | P54132 | 2/20 | 0.41 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL6095324 | 0.86 | TSHR (0.69) | TSHRTP53EGLN1EGLN3CA5A | |
| Maleic Acid SCHEMBL11860272 | 0.86 | TSHR (0.69) | TSHRTP53EGLN1EGLN3CA5A | |
| Fumaric Acid SCHEMBL6095338 | 0.86 | TSHR (0.69) | TSHRTP53EGLN1EGLN3CA5A | |
| Maleic Acid SCHEMBL2883980 | 0.84 | TSHR (0.56) | TSHRTP53EGLN1EGLN3CA1 | |
| Fumaric Acid SCHEMBL930728 | 0.84 | TSHR (0.56) | TSHRTP53EGLN1EGLN3CA1 | |
| Fumaric Acid SCHEMBL930726 | 0.84 | TSHR (0.56) | TSHRTP53EGLN1EGLN3CA1 | |
| Fumaric Acid SCHEMBL9813915 | 0.83 | TSHR (0.64) | TSHRTP53EGLN1EGLN3CA5A | |
| Maleic Acid SCHEMBL11768683 | 0.83 | TSHR (0.64) | TSHRTP53EGLN1EGLN3CA5A | |
| Fumaric Acid SCHEMBL7551164 | 0.83 | TSHR (0.64) | TSHRTP53EGLN1EGLN3CA5A | |
| Maleic Acid SCHEMBL9813908 | 0.83 | TSHR (0.64) | TSHRTP53EGLN1EGLN3CA5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5498373-A | AMINOPOLYACETATE CHELATING COMPOUND; MALATE, MALEATE OR SUCCINATE | THE PROCTER & GAMBLE COMPANY (US) | 1996-03-12 | — | — | US | disclosed |
| US-5466870-A | Oxidation of tertiary amine in presence of polycarboxylate chelating compound | THE PROCTER & GAMBLE COMPANY (US) | 1995-11-14 | — | — | US | disclosed |