Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 7/20 | 0.65 |
| ▸ | HTR1B | P28222 | 8/20 | 0.64 |
| ▸ | HTR1D | P28221 | 5/20 | 0.64 |
| ▸ | GABRP | O00591 | 4/20 | 0.61 |
| ▸ | GABRD | O14764 | 4/20 | 0.61 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.61 |
| ▸ | GABRB1 | P18505 | 4/20 | 0.61 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.61 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.61 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.61 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.61 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.61 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.61 |
| ▸ | GABRA4 | P48169 | 4/20 | 0.61 |
| ▸ | GABRE | P78334 | 4/20 | 0.61 |
| ▸ | GABRA6 | Q16445 | 4/20 | 0.61 |
| ▸ | GABRG1 | Q8N1C3 | 4/20 | 0.61 |
| ▸ | GABRG3 | Q99928 | 4/20 | 0.61 |
| ▸ | GABRQ | Q9UN88 | 4/20 | 0.61 |
| ▸ | HTR1A | P08908 | 3/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8979700 | 0.84 | HTR1B (0.68) | HTR6HTR1BHTR1DGABRPGABRD | |
| SCHEMBL8472864 | 0.83 | HTR1B (0.64) | HTR6HTR1BHTR1DGABRPGABRD | |
| SCHEMBL8979714 | 0.82 | HTR1B (0.63) | HTR6HTR1BHTR1DGABRPGABRD | |
| SCHEMBL8979850 | 0.82 | HTR1B (0.60) | HTR6HTR1BHTR1DGABRPGABRD | |
| SCHEMBL8475793 | 0.80 | HTR6 (0.63) | HTR6HTR1BHTR1DGABRPGABRD | |
| SCHEMBL28009738 | 0.80 | HTR6 (0.62) | HTR6HTR1BHTR1DGABRPGABRD | |
| SCHEMBL772623 | 0.79 | HTR6 (1.00) | HTR6HTR1BHTR1DGABRPGABRD | |
| SCHEMBL798334 | 0.79 | HTR6 (1.00) | HTR6HTR1BHTR1DGABRPGABRD | |
| SCHEMBL29827369 | 0.79 | HTR6 (1.00) | HTR6HTR1BHTR1DGABRPGABRD | |
| SCHEMBL8686525 | 0.79 | HTR1B (0.67) | HTR6HTR1BHTR1DHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5502065-A | TREATING HEADACHES | PFIZER INC. (US) | 1996-03-26 | — | — | US | disclosed |
| WO-1993021178-A1 | INDOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS | PFIZER LIMITED (GB) | 1993-10-28 | — | — | WO | disclosed |