Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | APAF1 | O14727 | 1/20 | 0.46 |
| ▸ | RGS12 | O14924 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PARP4 | Q9UKK3 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6288870 | 0.85 | BDKRB2 (0.44) | RAB9AALDH1A1MAPTHSD17B3 | |
| SCHEMBL2480571 | 0.84 | RARB (0.50) | KMT2AMEN1ALDH1A1TSHRMAPT | |
| SCHEMBL28435445 | 0.84 | KMT2A (0.44) | MAPK1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL961840 | 0.83 | MAPT (0.47) | KMT2AMEN1ALDH1A1CA1CA2 | |
| SCHEMBL4766583 | 0.81 | HSD17B3 (0.55) | SMN1; SMN2NPC1L3MBTL1HSD17B3 | |
| SCHEMBL1983658 | 0.80 | TSHR (0.32) | KMT2AMEN1CYP2C9TSHRMAPT | |
| SCHEMBL8979725 | 0.80 | PARP1 (0.46) | MAPK1KMT2AMEN1APAF1RGS12 | |
| SCHEMBL5952565 | 0.79 | NPC1 (0.50) | KMT2AMEN1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL4769427 | 0.79 | PLK1 (0.58) | SMN1; SMN2CA1CA2TSHRL3MBTL1 | |
| SCHEMBL9596990 | 0.79 | HPGD (0.44) | SMN1; SMN2ALDH1A1TLR8EPHX2HSD17B3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5502065-A | TREATING HEADACHES | PFIZER INC. (US) | 1996-03-26 | — | — | US | disclosed |
| EP-0636129-A1 | INDOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS | Pfizer Limited (GB) | 1995-02-01 | — | — | EP | disclosed |
| US-5258509-A | Catalytic detherification and alkylation | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1993-11-02 | — | — | US | disclosed |
| WO-1993021178-A1 | INDOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS | PFIZER LIMITED (GB) | 1993-10-28 | — | — | WO | disclosed |
| EP-0430037-A2 | Process for producing 2-carbon-substituted carbapenem derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1991-06-05 | — | — | EP | disclosed |